Reza Shirkoohi
Cancer Models Research Center, Cancer Institute of Iran, Tehran University of Medical Sciences, Tehran, Iran
[ 1 ] - Feasibility assessment of in vitro chemoresponse assay on stereotactic biopsies of glioblastoma multiforms: a step towards personalized medicine
Objective(s):P In vitro chemosensitivity and resistance assays (CSRAs) are a promising tool for personalized treatment of glioblastoma multiform (GBM). These assays require a minimum of 1 to 2 g of tumor specimen for testing, but this amount is not always accessible. We aimed to assess the feasibility and validity of utilizing stereotactic biopsies of GBM in CSRAs. Materials and Methods: Single...
[ 2 ] - Human cytomegalovirus infection in tumor specimens of Iranian patients with glioma
Human cytomegalovirus (HCMV) causes persistent infection in humans and severe diseases in fetus andimmunocompromised individuals. Although HCMV is not currently implicated in human cancer, emerging evidence suggests that HCMV infection might be specifically associated with some human malignancies including glioma. Glioma is one of the most common brain tumors affecting children and adults. In t...
[ 3 ] - شناسایی پروتئین 65 PPسایتومگالوویروس انسانی در تومورهای مغزی گلیووما با روش ایمنوهیستوشیمی
زمینه: سایتومگالوویروسهای انسانی ممکن است در ایجاد بیماری گلیوما که یکی از شایعترین تومورهای مغزی است، نقش داشته باشند. هدف: مطالعه به منظور شناسایی سایتومگالوویروسهای انسانی در بیماران مبتلا به گلیوما در بیمارستان امام خمینی تهران انجام شد. مواد و روشها: این مطالعه تجربی در سال 1391 بر روی نمونههای پارافینه تومور مغزی گلیومای بیماران مراجعهکننده به بخش جراحی اعصاب بیمارستان امام خم...
[ 4 ] - BIRC5 Genomic Copy Number Variation in Early-Onset Breast Cancer
Background: Baculoviral inhibitor of apoptosis repeat-containing 5 (BIRC5) gene is an inhibitor of apoptosis that expresses in human embryonic tissues but it is absent in most healthy adult tissues. The copy number of BIRC5 has been indicated to be highly increased in tumor tissues; however, its association with the age of onset in breast cancer is not well understood. Methods: Forty tumor tiss...
[ 5 ] - تعیین سطح بیان ژن‌های E-cadherin و Vimentin در نمونههای توموری بیماران مبتلا به سرطان تخمدان
Background: Ovarian cancer is a leading metastatic disease. The epithelial ovarian cancer is one of the most common malignant cancers that usually remains asymptomatic up to metastasis stages, and most patient when diagnosed are in the advanced stage of the disease. Studies have shown that in the majority of epithelial cancers mesenchymal factor expression such as Vimentin increases, and the ep...
[ 6 ] - ارتباط بیان ژن اوکلودین با مشخصات بالینی و مورفولوژیک سرطان پستان
Background: Breast cancer is the second most common cancer in the world after lung cancer also is the fifth cause of cancer mortality. About 90 percent of cancer mortality is because of metastasis and devastating between cell attachments, especially tight cell junctions. Epithelial mesenchymal transition is a phenomena involved in metastasis and starts with cell detachment. Occludin is the inte...
[ 7 ] - The Impact of Long-term Exposure to Low Levels of Inorganic Arsenic on the Hypomethylation of SEPT9 Promoter in Epithelial-Mesenchymal Transformed Colorectal Cancer Cell Lines
Inorganic arsenicals are worldwide environmental contaminants that affect molecular characteristics in biological systems and lead to genomic and epigenomic instability as well as epithelial mesenchymal transition (EMT). In this study, we aimed to investigate whether low levels of sodium arsenite (iAsIII) can influence EMT and genomic instability through microsatellite analysis. We have also de...
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