Renate Griffith
School of Medical Sciences/Pharmacology, University of New South Wales, Sydney, NSW 2052, Australia School of Environmental and Life Sciences, University of Newcastle, NSW 2308, Australia
[ 1 ] - Differences in growth promotion, drug response and intracellular protein trafficking of FLT3 mutants
Objective(s): Mutant forms FMS-like tyrosine kinase-3 (FLT3), are reported in 25% of childhood acute lymphoid leukemia (ALL) and 30% of acute myeloid leukemia (AML) patients. In this study, drug response, growth promoting, and protein trafficking of FLT3 wild-type was compared with two active mutants (Internal Tandem Duplication (ITD)) and D835Y. Materials and Methods:FLT3 was expressed on fact...
نویسندگان همکار