Pedram Ebrahimnejad

[ 1 ] - Evaluation of the effect of physical variables on in vitro release of diclofenac pellets using Box-Behnken design

Objective(s): A Box-Behnken design was used for evaluation of Eudragit coated diclofenac pellets. The purpose of this work was to optimize diclofenac pellets to improve the physicochemical properties using experimental design. Materials and Methods: Diclofenac was loaded onto the non-pareil beads using conventional coating pan. Film coating of pellets was done at the same pan. The effect of pla...

[ 2 ] - Synthesizing and Characterizing Functionalized Short Multiwall Carbon Nanotubes with Folate, Magnetite and Polyethylene Glycol as Multitargeted Nanocarrier of Anti-cancer Drugs

Multifunctional nanomaterials showed graet advantages in drug delivery. Folic acid (FA) binding protein, a glycosyl phosphatidyl inositol anchored cell surface receptor for folate, is overexpressed in several human tumors, whereas it is highly restricted in normal tissues. Therefore, in this study, FA, polyethylene glycol (PEG), and Fe3O4 nanoparticles multifunctionalized short multiwall carbon...

[ 3 ] - Green Synthesis of Silver Nanoparticles Using Mentha aquatic L Extract as the Reducing Agent

Background: Developing effective methods for the synthesis of bio-compatible and non-toxic nanoparticles is the main goal of nanotechnology. In the most chemical methods, a chemical reducing agent is used to reduce metal ions. But, in chemical methods, the stability of nanoparticles is controversial and synthesis in large sizes is much more difficult. Moreover, there is an incr...

[ 4 ] - Encapsulation of irinotecan in polymeric nanoparticles: Characterization, release kinetic and cytotoxicity evaluation

Objective(s): Irinotecan is a potent anti-cancer drug from camptothecin group which inhibits topoisomerase I. Recently, biodegradable and biocompatible polymers such as poly lactide-co-glycolides (PLGA) have been considered for the preparation of nanoparticles (NPs). Materials and Methods: In this study, irinotecan loaded PLGA NPs were fabricated by an emulsification/solvent diffusion method to...

[ 5 ] - Synthesizing and Characterizing Functionalized Short Multiwall Carbon Nanotubes with Folate, Magnetite and Polyethylene Glycol as Multitargeted Nanocarrier of Anti-cancer Drugs

Multifunctional nanomaterials showed graet advantages in drug delivery. Folic acid (FA) binding protein, a glycosyl phosphatidyl inositol anchored cell surface receptor for folate, is overexpressed in several human tumors, whereas it is highly restricted in normal tissues. Therefore, in this study, FA, polyethylene glycol (PEG), and Fe3O4 nanoparticles multifunctionalized short multiwall carbon...

[ 6 ] - Anti-Bacterial Property and Cytotoxicity of Allium Sativum and Myrtus Communis Extracts against Nosocomial Bacterial Infections

Background: Microbial infections and the resistance to antibacterial drugs are on the rise, and scientists are in search of the safest and most effective approach to overcome them. Medicinal plants are potentially effective against many microorganisms. Therefore, this study was planned to examine the antibacterial properties and cytotoxicity of the extracts of Allium sativum and Myrtus communis...