Majid Asadi-shekaari

[ 1 ] - Melatonin treatment reduces astrogliosis and apoptosis in rats with traumatic brain injury

Objective(s):Melatonin is known as an anti-inflammatory agent, and it has been proven to exert neuroprotection through inhibition of cell death (apoptosis) in several models of brain injury.Secondary injury following the primary traumatic brain injury (TBI) results in glial cells activation, especially astrocytes. In fact, astrocyte activation causes the production of pro-inflammatory cytokines...