Mohammad Amin Kerachian

[ 1 ] - Apoptosis inducing capacity of Holothuria arenicola in CT26 colon carcinoma cells in vitro and in vivo

Objective(s):Sea cucumber is one of the classes of echinoderms, which is considered as a health marine product and possess various biological characteristics with therapeutic application. The present investigation attempted to evaluate the potential of anti-cancer Persian Gulf sea cucumber species Holothuria arenicola (H. arenicola) aqueous extract on mice colon carcinoma cells in vitro and in ...

[ 2 ] - The effect of Islamic fasting in Ramadan on osteoporosis

Osteoporosis is considered as one of the most common diseases that women face after their menopause and is caused by both genetic and environmental factors.  Dipeptidyl peptidase 4 (DPP-4) gene is one of the important genetic factors contributing in osteoporosis which has a direct and very important relationship with fasting. Fasting is one of the alternatives proved to reduce the DPP-4 level a...

[ 3 ] - Fasting and Experimental Animals, Detrimental or Positive?

While fasting has been practiced for centuries, its beneficial effects was unknown until recently. This review tries to analyze the current literature of how fasting and intermittent fasting (IF) could affect clinical pathological parameters, learning, mood and brain plasticity. The effects of different ways of fasting on metabolism and stress were also explored. Animal experiments have elucida...

[ 4 ] - Fasting in a 16-year-old girl at-risk of autosomal dominant polycystic kidney disease

Autosomal dominant polycystic kidney disease (ADPKD) is the most common form of inherited kidney disease that results in renal failure. PKD currently has no causative therapy. However, some treatment options are available, ranging from symptomatic therapy to delaying the onset of end-stage renal failure. Early diagnosis of adult polycystic kidney disease is vital in order to prevent its complic...

[ 5 ] - Cell fasting: Cellular response and application of serum starvation

  Humans suffer transient or persistent starvation due to a lack of food intake, either because of fasting, voluntary dieting, or due to the scarcity of available food. At the cellular level it is possible to possess pathological starvation during ischemia and solid tumors. Blood provides many nutrients to our cells, and researchers provide these nutrients to cells in culture in the form of en...

[ 6 ] - The effect of fasting on the important molecular mechanisms related to cancer treatment

Fasting does have remarkable benefits in the treatment of cancer and another diseases such as metabolic syndrome, diabetes, and a multitude of other chronic diseases. It has been determined that fasting could play an important role during cancer treatment and progression via the regulation of insulin-like growth factor-1 (IGF-1) as well as other growth factors. Also, it has been shown that fast...

[ 7 ] - Is esophageal atresia a natural way of fasting?

[ 8 ] - High Serum Alpha-2-Macroglobulin Level in Patients with Osteonecrosis of the Femoral Head

  Background: Diagnosis of osteonecrosis of the femoral head (ONFH) is complicated due to the lack of reliable serum biomarkers. Up-regulation of alpha-2-macroglobulin (A2M) gene has been reported in glucocorticoid-induced ANFH rat model. This study aimed to investigate whether the serum level of alpha-2-macroglobulin (A2M) can be used for ONFH diagnosis. Methods: Serum protein capillary elect...

[ 9 ] - Avascular Necrosis of the Femoral Head: Are Any Genes Involved?

Avascular necrosis of the femoral head (ANFH) is a pathologic process that results from interruption of blood supply to the femur bone resulting in the death of bone cells and collapse of the femoral head. Nontraumatic ANFH continuesto be a significant challenge to orthopedic surgeons. While the exact mechanisms remain elusive, many new insights have emerged from research in the last decade tha...

[ 10 ] - Molecular Aspects of Co-morbidities in COVID-19 Infection

Coronaviruses are a group of enveloped viruses with single-stranded non-segmented positive-sense RNA genomes. InDecember 2019, SARS-CoV-2 appeared in China for the first time and quickly spread throughout the world. Althoughcertain medications suggested for other afflictions tend to be potentially effective for curing the infection, there is noapproved vaccination or drug avai...

[ 11 ] - Multiplex-Polymerase Chain Reaction for Detecting Microdeletions in The Azoospermia Factor Region of Y Chromosome in Iranian Couples with Non-Obstructive Infertility and Recurrent Pregnancy Loss

Objective Approximately 15 percent of couples are infertile. The male factor is responsible for approximately 50% of the cases. One of the main genetic factors playing a role in male infertility is Y chromosomal microdeletion within the proximal long arm of the Y chromosome (Yq11), named azoospermia factor (AZF) region. Recent studies have also demonstrated that there is a potential connection ...

[ 12 ] - The effect of Cannabis sativa extract on damages induced by electromagnetic fields on ovarian follicle maturation and hormonal surface changes in mice

Electromagnetic waves (EMF) are a mixture of electrical and magnetic waves. The energy transmitted by these radiations is absorbed by living tissues. Electromagnetic fields seem to cause infertility in women. Cannabis is annual herbaceous plant grows in tropical areas. This study was conducted to investigate the protective effects of hydroalcoholic extract of Cannabis sativa in various doses of...