Ehsan Saboory

[ 1 ] - Effect of magnesium sulfate on hyperthermia and pentylen-tetrazol-induced seizure in developing rats

Objective(s): Febrile seizures (FS) are the most common type of convulsive events among children. Its prevalence has been estimated to be 2-5% in children between 3 months and 5 years old. Also, blood and CSF magnesium levels have been demonstrated to be reduced in children with FS. This study investigates the effect of MgSo4 pretreatment on the behaviors caused by hyperthermia (HT) and effect ...

[ 2 ] - Effect of Restraint Stress during Gestation on Pentylenetetrazol-Induced Epileptic Behaviors in Rat Offspring

Objective(s): Epilepsy is a neurodevelopmental disorder which is strongly influenced by genetic and environmental factors. Gestational stress has been shown to be an important factor for affecting seizure susceptibility. The present study was conducted to address whether gestational stress may affect pentylentetrazol (PTZ)-induced epileptic behavior in rat offspring in a sex- and a...

[ 3 ] - Modulation of Basal Glutamatergic Transmission by Nicotinic Acetylcholine Receptors in Rat Hippocampal Slices

Objective(s) Nicotinic acetylcholine receptors (nAChRs) regulate epileptiform activity and produce a sustained pro-epileptogenic action within the hippocampal slices. In the present study, we investigated the effect of nAChRs on evoked glutamatergic synaptic transmission in area CA3 and CA1 of rat hippocampal slices to identify possible excitatory circuits through which activation of nAChRs pr...

[ 4 ] - Time Dependent Antinociceptive Effects of Morphine and Tramadol in the Hot Plate Test: Using Different Methods of Drug Administration in Female Rats

Morphine and tramadol which have analgesic effects can be administered acutely or chronically. This study tried to investigate the effect of these drugs at various times by using different methods of administration (intraperitoneal, oral, acute and chronic). Sixty adult female rats were divided into six groups. They received saline, morphine or tramadol (20 to 125 mg/kg) daily for 15 days. A ho...

[ 5 ] - Time Dependent Antinociceptive Effects of Morphine and Tramadol in the Hot Plate Test: Using Different Methods of Drug Administration in Female Rats

Morphine and tramadol which have analgesic effects can be administered acutely or chronically. This study tried to investigate the effect of these drugs at various times by using different methods of administration (intraperitoneal, oral, acute and chronic). Sixty adult female rats were divided into six groups. They received saline, morphine or tramadol (20 to 125 mg/kg) daily for 15 days. A ho...

[ 6 ] - مقایسه سطح لپتین شیر مادران دارای فرزند دختر و پسر

سابقه و هدف: مطالعات نشان داده‌اند که سطح لپتین خون دختران بیش‌تر از پسران است، ولی گزارشی در مورد تفاوت سطح لپتین شیر مادر بر حسب جنسیت جنین و یا شیر‌خوار وجود ندارد. بنابراین، هدف پژوهش حاضر بررسی تاثیر جنسیت فرزند بر سطح لپتین شیر مادر بود. مواد و روش ‌ ها: با مراجعه به مراکز بهداشتی واقع در شهر ارومیه، از بین مادران شیرده مراجعه‌کننده به مراکز بهداشتی شهر ارومیه 115 نفر انتخاب شدند. پرس...

[ 7 ] - پاسخ پروفایل چربی و کورتیزول سرمی به یک جلسه فعالیت هوازی شدت متوسط در مردان میان‌سال غیر فعال

Background & Aims : Incidence of cardiovascular disease and stroke can be due to decreased mobility or non-suitable life style. Exercise induces changes in blood lipids, cortisol . The aim of this study was to evaluate response of serum cortisol and lipid profile to a moderately intensive aerobic exercise in non-active middle-aged men . Materials & Methods: Thirty middle-aged men with an ...

[ 8 ] - بررسی ارتباط استرس دوران بارداری با عاقبت بارداری: یک مطالعه طولی

پیش‌زمینه و هدف: دوران حاملگی از پراسترس‌ترین دوران زندگی معمول یک زن می‌باشد. استرس در شرایط بارداری، زایمان و شیردهی می‌تواند با نتایج نامطلوب بارداری همراه باشد. با توجه به اهمیت سلامت روان در دوران بارداری که می‌تواند تأثیر به سزایی در سلامتی روانی و جسمانی مادر و کودک داشته باشد؛ بران شدیم تا مطالعه‌ای را باهدف تعیین رابطه بین استرس دوران بارداری با عاقبت بارداری در مادران باردار شهرستان م...

[ 9 ] - مقایسه اثر دو نوع استرس دوران بارداری روی میزان کورتیکو سترون خون و گیرنده های تحریکی مغز

مقدمه: استرس مادران در دوران بار داری می تواند یک فاکتور بالقوه در ایجاد برخی از بیماری ها نورو لوژیک باشد. مسیر بیو شیمیایی در پاسخ به استرس ها ترشح فاکتور آزاد کننده کورتیکو تروپین CRF از هسته پارا ونتریکولار است که منجر به تحریک ترشحACTH و نهایتا افزایش گلوکو کورتیکوئید های پلاسما می شوند. افزایش سطح کورتیکو سترون خون CBL در نوزادان موش های صحرایی نشان دهنده القا استرس دوران بار داری...

[ 10 ] - اثر مرفین بر حملات صرعی ایجاد شده بوسیله مایع مغزی نخاعی با منیزیم کم در هیپوکامپ کامل موش

Introduction & Objective: Morphine has both anti and proconvulsive actions on the epileptiform activity depending on the exact experimental conditions. Study of the contraversy effects of morphine on certain neural activities such as epilepsy leads to clearify some neural events and neuronal adaptations. This study was designed to determine the effect of morphine on seizure induced by Low Mg2...

[ 11 ] - Effect of dexamethasone on the convulsive behavior induced by hyperthermia: possible role of histamine

Introduction: Febrile seizures are the most common seizure disorder in childhood and its prevalence is estimated to be 2 to 5 percent. There is a relationship between the use of corticosteroids and seizures. This study investigated the effects of dexamethasone pretreatment on convulsive behavior caused by hyperthermia. Methods: In this study, 24 rats aged 19-20 days were divided into 3 group...

[ 12 ] - Comparison of the effects of Chronic Morphine and Tramadol Administration during neonatal period on pain threshold of immature rat

Introduction: Amongst the medications to reduce pain, morphine as an important natural and tramadol as an important synthetic drug have been mostly considered. There are few studies on the comparison of the analgesic effect of these drugs in neonatal and perpubertal periods. Methods: Neonate rats (n=49) were randomly divided into three groups. On postnatal days 8-14, one group received s...

[ 13 ] - Exposure to Predator Stress in Gestational Period Potentiates Pilocarpine induced Epileptic Behaviors in offspring of rat

Introduction: Gestational stress can lead to cerebral functional disorders, such as epilepsy, probably due to the disturbance in the cerebral maturation and causing abnormal neuronal correlations. In the present study, effect of gestational Predator Stress on the neonatal epileptic behaviors was investigated in rats. Methods: Female rats (200 ± 20 g) were divided into two groups intact pregn...

[ 14 ] - مقایسه اثر تجویز مزمن مورفین و ترامادول در دوره شیرخواری بر تشنج حاد حاصل از پنتیلن تترازول در موش صحرایی نابالغ

Background: It is demonstrated that morphine and tramadol affects seizure but the mode of action of these drugs on seizure has not been compared yet with increasing of age. The aim of this study was to compare the impact of exposure to these drugs on Pentylenetetrazol-induced seizure in immature rat.Methods: Male neonate rats were randomly chosen and divided into three groups namely Saline (n=2...