Elham Karimi Sales

[ 1 ] - Trans-chalcone enhances insulin sensitivity through the miR-34a/SIRT1 pathway

Objective(s): Trans-chalcone as the parent member of the chalcone series reduces circulating levels of insulin and glucose. However, the cellular mechanism of these effects is poorly understood. Sirtuin 1 (SIRT1) as a direct target of miR-34a controls homeostasis of glucose, and also improves insulin sensitivity. Therefore, the present study for the first time investigated the influence of tran...