Mehdi Mehdizadeh
Department of Anatomical Sciences, School of Medicine, Iran University of Medical Sciences, Tehran, Iran
[ 1 ] - Gestational diabetes influences the expression of hypertrophic genes in left ventricle of rat’s offspring
Objective(s): Gestational diabetes increases the risk of congenital heart disease in the offspring, but the molecular mechanism underlying this process remains unclear. Therefore, the current study was conducted to assess the effects of induced gestational diabetes on expression of some involved genes in cardiac hypertrophy in the offspring of diabetic rats.Materials and Methods: Diabetes was i...
[ 2 ] - Gestational diabetes influences retinal Muller cells in rat's offspring
Objective(s): The Muller cell is the principal glial cell of the vertebrate retina. The expression of Glial fibrillary acidic protein (GFAP) in the Muller cells was used as a cellular marker for retinal damage. This study was done to evaluate the effect of gestational diabetes on retinal Muller cells in rat's offspring. Materials and Methods: In this experimental study, 12 Wistar rat dams were ...
[ 3 ] - Combination of Stem Cell Mobilized by Granulocyte-Colony Stimulating Factor and Human Umbilical Cord Matrix Stem Cell: Therapy of Traumatic Brain Injury in Rats
Objective(s) Clinical studies of treating traumatic brain injury (TBI) with autologous adult stem cells led us to examine the impression of a combination therapy. This was performed by intravenous injection of human umbilical cord matrix stem cell (hUCMSC-Wharton,s jelly stem cell) with bone marrow cell mobilized by granulocytecolony stimulating factor (G-CSF) in rats injured with cortical com...
[ 4 ] - اثر عصاره هیدروالکلی چای سبز (Camellia sineisis L) بر گلوکز خون و وزن موش‌های صحرائی نر دیابتی شده با استرپتوزوتوسین
زمینه و هدف : امروزه استفاده از گیاهان دارویی برای تخفیف علائم و درمان بیماری دیابت مورد توجه قرار گرفته که از جمله می‌توان به چای سبز (Camellia sinesis L.) اشاره نمود، ولی با توجه به عدم بیان دوز مناسب و متناقض بودن نتایج در مورد اثرات آن بر میزان قندخون، این مطالعه به منظور تعیین اثر عصاره آن در دوزهای مختلف بر قندخون و کاهش وزن در موش‌های دیابتی شده با استرپتوزوتوسین انجام شد. روش بررسی: ای...
[ 5 ] - Research Paper: The Effect of Callistephin on Amyloid Beta-Induced Neurotoxicity in the Hippocampus of Male Rats
Introduction: Oxidative stress plays a key role in the pathophysiology of the Alzheimer's disease and it seems that antioxidants may slow the progress of the disease. The current study aimed at investigating the possible protective effects of callistephin (a natural flavonoid) against amyloid β (Aβ)-induced neurogenesis deficits in rats. Methods: Adult Wistar male rats in the current...
[ 6 ] - The effect of 3,4- methylenedioxymethamphetamine on expression of neurotrophic factors in hippocampus of male rats
Background: 3,4- methylenedioxymethamphetamine (MDMA) is a chemical derivative of amphetamine that can induce learning and memory impairment. Due to the effect of neurotrophins on memory and learning, the impact of MDMA was evaluated on the brain - derived neurotrophic factor (BDNF), neurotrophin- 4 (NT-4), and tropomyosin- related kinase B (Trk- β) expression in the hipp...
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