Abbas Haghparast
Neuroscience Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
[ 1 ] - Neuroprotective effects of gallic acid in a rat model of traumatic brain injury: behavioral, electrophysiological and molecular studies
Objective(s): Traumatic brain injury (TBI) is one of the main causes of intellectual and cognitive disabilities. Clinically, it is essential to limit the development of cognitive impairment after TBI. In the present study, the neuroprotective effects of gallic acid (GA) on neurological score, memory, long-term potentiation (LTP) from hippocampal dentate gyrus (hDG), brain lipid peroxidation an...
[ 2 ] - Blockade of the Naloxone-induced Aversion in Morphine-conditioned Wistar Rats by L-Arginine Intra-central Amygdala
Objective(s) Single injection of naloxone, a selective antagonist of morphine, prior to the drug conditioning testing was used to investigate on morphine dependence. Materials and Methods Conditioning to morphine (2.5-10 mg/kg, s.c.) was established in adult male Wistar rats (weighing 200-250 g) using an unbiased procedure. Nitric oxide agents were microinjected into the central amygdala pri...
[ 3 ] - Intra-accumbal orexin-1 receptors are involved in antinociception induced by stimulation of the lateral hypothalamus in the formalin test as an animal model of persistent inflammatory pain
Orexin, mainly produced by orexin-expressing neurons in the lateral hypothalamus (LH), plays an important role in pain modulation. Moreover, it is shown that the nucleus accumbens (NAc) is one of the important areas involved in this modulation. Orexin-1 (OX1) and orexin-2 (OX2) receptors are densely distributed in the NAc. The study investigated the involvement of OX1 receptors in the NAc on an...
[ 4 ] - Intra-accumbal orexin-1 receptors are involved in antinociception induced by stimulation of the lateral hypothalamus in the formalin test as an animal model of persistent inflammatory pain
Orexin, mainly produced by orexin-expressing neurons in the lateral hypothalamus (LH), plays an important role in pain modulation. Moreover, it is shown that the nucleus accumbens (NAc) is one of the important areas involved in this modulation. Orexin-1 (OX1) and orexin-2 (OX2) receptors are densely distributed in the NAc. The study investigated the involvement of OX1 receptors in the NAc on an...
[ 5 ] - The Fruit Essential oil of Cuminum cyminum L. Reduced the Acquisition but not Expression of Ineffective dose of Morphine-Induced Conditioned Place Preference in Morphine- Sensitized Mice
Background: Cuminum cyminum fruit essential oil (FEO) dose-dependently can attenuate the expression of morphine tolerance and dependence in morphine-dependent mice. Objective: In this study, the effects of Cuminum cyminum FEO on acquisition and expression of morphine-induced conditioned place preference (CPP) in morphine-sensitized mice were studied. Methods: Repeated subcutaneous (s.c.) adm...
[ 6 ] - تغییر فاکتورهای آپوپتوزی PARP, Caspase-3 و نسبت Bax/Bcl-2 در ناحیه تگمنتوم شکمی پس از اکتساب ترجیح مکان شرطی و دوره ترک مصرف مورفین در موش بزرگ آزمایشگاهی
سابقه و هدف: تحقیقات پیشین نشان داده‌اند که مورفین مزمن القا‌کننده آپوپتوز می‌باشد. از جمله مراکز اصلی در مدار پاداش ناحیه تگمنتوم شکمی (Ventral tegmental area, VTA) می‌باشد. تحریک مسیر پاداش در مغز توسط مورفین می‌تواند از طریق فعال کردن رسپتورهای اپیوئیدی سبب القاء فاکتورهای آپوپتوزی در برخی از مناطق مغزی شود و بیان رسپتورهای مرگ را در سطح سلول افزایش دهد. در این مطالعه تغییر فاکتورهای...
[ 7 ] - اثر غیر فعال‌سازی ناحیه تگمنتوم شکمی بر میزان و الگوی فعالیت نورون‌های بخش پوسته هسته اکومبنس و تأثیر آن بر ترجیح مکان شرطی ناشی از مورفین در موش صحرایی
سابقه و هدف: سیستم دوپامینرژیک مزولیمبیک که از ناحیه تگمنتوم شکمی به هسته اکومبنس انشعابات وابران می‌دهد، دارای نقش اساسی در تقویت حاصل از مورفین و اثرات پاداشی داروهای مورد سوء مصرف می‌باشد. در مطالعه حاضر اثرات غیر فعال‌سازی برگشت‌پذیر ناحیه تگمنتوم شکمی بر میزان فعالیت الکتریکی نورون‌های هسته اکومبنس و اکتساب و بیان ترجیح مکان شرطی القا‌شده توسط مورفین در موش صحرایی بررسی گردید. مواد و ر...
[ 8 ] - بررسی چگونگی مقاومت در درمان لیشمانیوز جلدی با مگلومین آنتی‌موان (گلوکانتیم): مقایسه حساسیت انگل جدا شده از بیمار به دارو در محیط کشت با پاسخ کلینیکی بیمار به درمان
سابقه و هدف: با توجه به اینکه درمان اساسی در بیماری لیشمانیوز با ترکیبات آنتی‌موان، شامل پنتوستام و گلوکانتیم، صورت می‌گیرد و مقاومت داروئی بیمار به این ترکیبات خصوصاً در مناطق اندمیک یکی از مشکلات اصلی در این بیماری است. این مطالعه، جهت ارزیابی حساسیت و یا مقاومت سوش‌های Leishmania tropica جدا شده از بیماران را در محیط کشت و در حالت تکثیر داخل سلولی (فر...
[ 9 ] - پاسخ ضد دردی وابسته به دوز مرفین تزریق شده در هسته میخی شکل (Cuneiformis) و تاثیر غیرفعال کردن این ناحیه بر تعدیل درد در موش صحرایی
سابقه و هدف: هسته میخی شکل (CnF ،Cuneiformis) یک هسته مشبک مغز میانی است که در ناحیه شکمی-طرفی ماده خاکستری دور قناتی (PAG ،Periaqueductal gray) قرار گرفته و به طور غیرمستقیم از طریق ناحیه نوکی بصل النخاع شکمی-میانی (RVM ،Rostral ventromedial medulla) در تعدیل درد نقش دارد. این هسته با PAG شباهت ساختمانی داشته و با آن ارتباطات زیادی برقرار می کند. لذا در مطالعه حاضر با توجه به تشابه ساختمانی و ...
[ 10 ] - Effects of Acute and Chronic Restraint Stress on Reinstatement of Extinguished Methamphetamine-induced Conditioned Place Preference in Rats
Introduction: Methamphetamine (METH) is a neurotoxic psychostimulant with highly addictive potential that leads to compulsive drug use and vulnerability to relapse. Environmental cues, such as drug exposure, peer influence, and social stress, are the powerful triggers of drug relapse. In this study, we tried to find out the effect of acute and chr...
[ 11 ] - The Impact of Audio Book on the Elderly Mental Health
Introduction: The growing elderly population calls mental health professionals to take measures concerning the treatment of the elderly mental disorders. Today in developed countries, bibliotherapy is used for the treatment of the most prevalent psychiatric disorders. Therefore, this study aimed to investigate the effects of audio book on the elderly mental health of Retirement Center of Shahid...
[ 12 ] - Reduction of the Morphine Maintenance by Blockade of the NMDA Receptors during Extinction Period in Conditioned Place Preference Paradigm of Rats
Introduction: Activation of N-methyl-d-aspartate (NMDA) glutamate receptors in the nucleus accumbens is a component of drug-induced reward mechanism. In addition, NMDA receptors play a major role in brain reward system and activation of these receptors can change firing pattern of dopamine neurons. Blockade of glutamatergic neurotransmission reduces the expression of conditi...
[ 13 ] - Effects of Dimethyl Sulfoxide on Neuronal Response Characteristics in Deep Layers of Rat Barrel Cortex
Introduction: Dimethyl sulfoxide (DMSO) is a chemical often used as a solvent for waterinsoluble drugs. In this study, we evaluated the effect of intracerebroventricular (ICV) administration of DMSO on neural response characteristics (in 1200–1500 μm depth) of the rat barrel cortex. Methods: DMSO solution was prepared in 10% v/v concentration and injected into the later...
[ 14 ] - Focal Injection of Ethidium Bromide as a Simple Model to Study Cognitive Deficit and Its Improvement
Introduction: Memory and cognitive impairments are some of devastating outcomes of Multiple Sclerosis (MS) plaques in hippocampus, the gray matter part of the brain. The present study aimed to evaluate the intrahippocampal injection of Ethidium Bromide (EB) as a simple and focal model to assess cognition and gray matter demyelination. Methods: Thirty Wistar rats were divided into three groups:...
[ 15 ] - The Blockade of D1/D2-Like Dopamine Receptors within the Dentate Gyrus of Hippocampus Decreased the Reinstatement of Morphine-Extinguished Conditioned Place Preference in Rats
Introduction: The hippocampus (HIP), the primary brain structure related to learning and memory, receives sparse but comprehensive dopamine innervations and contains dopamine D1/D2-like receptors. It is demonstrated that dopamine receptors in dentate gyrus (DG) region of HIP have a remarkable function in spatial reward processing. Much less is known about the involvement of HIP and its D1...
[ 16 ] - Microinjection of WIN55,212-2 as a Cannabinoid Agonist into the Basolateral Amygdala Induces Sensitization to Morphine in Rats
Introduction: Previous studies have shown that the basolateral amygdale (BLA) is rich of CB1 cannabinoid receptors and involved in cannabinoid-induced antinociception. Also, it seems that there are functional interactions between the cannabinoid CB1 and opioid receptors in the process of sensitization to opiates. In the present study, we tried to examine the role of intra-BLA cannabinoid rece...
[ 17 ] - گزارش موردی سپتی سمی باکتریایی ناشی از آئروموناس هیدروفیلا به همراه آلودگی شدید به هگزامیتاو کرم کاپیلاریا در فرشته ماهی، Pterophyllum scalare
سپتی‌سمی باکتریایی از جمله بیماری‌های مهم ماهی است که به صورت اولیه و یا به واسطه عوامل مساعد کننده به صورت ثانویه بروز می‌کند. آلودگی به انگل هگزامیتا کاپیلاریا نیز ازبیماری‌های مهم انگلی ماهی خصوصاً در ماهیان آکواریومی به حساب می‌آیند. هدف از این مطالعه، بررسی علت تلفات در فرشته ماهیهای یک مرکز تکثیر بود. در این مطالعه موردی، از یک مرکز تکثیر و پرورش ماهیان آکواریومی، تعداد 10 قطعه فرشته ماه...
[ 18 ] - بررسی پاسخ پاداشی هسته آکومبنس مغز پس از تزریق سلول های مزانکیمال بنیادی به دنبال دمیلیناسیون ناشی از اتیدیوم بروماید
مقدمه و هدف: دمیلیناسیون مهم ترین عارضه بیماری ام اس است که طی آن لایه میلین اطراف فیبرهای عصبی و هسته‌های مغزی دچار آپوپتوز یا مرگ سلولی می‌شوند. هسته آکومبنس یکی از هسته‌های ناحیه استریاتوم است که در پاسخ پاداشی مغز موثر است. رویکردی که اخیرا به آن توجه زیادی شده است سلول درمانی با استفاده از سلول‌های بنیادی است. بنابراین هدف این مطالعه بررسی پاسخ پاداشی هسته آکومبنس به دنبال تزریق سلول های م...
[ 19 ] - Lateral hypothalamus chemical stimulation-induced antinociception was attenuated by injection of dopamine D1 and D2 receptor antagonists in the ventral tegmental area
Introduction: Stimulation or inactivation of the lateral hypothalamus (LH) produces antinociception. Studies showed a role for the ventral tegmental area (VTA) in the antinociception induced by LH chemical stimulation through the orexinergic receptors. In this study, we assessed the role of intra-VTA dopamine D1 and D2 receptors in antinociceptive effects of cholinergic agonist, carbachol, m...
[ 20 ] - Effect of morphine on apoptotic factors caspase-3, PARP and Bax/Bcl-2 ratio in nucleus accumbens in conditioned place preference model in rat
Introduction: Nucleus accumbens (NAc) plays a critical role in neuronal reward circuits that are responsible for motivated and goal-directed behaviors. Some data suggest that morphine induces apoptosis in neurons, while other evidences show that morphine could have beneficial effects against neuronal cell death. This study was designed to evaluate the effect of morphine on apoptosis in the N...
[ 21 ] - Effect of glial inhibition in attenuation of neuropathic pain and improvement of morphine analgesic effect in a rat model of neuropathy
Introduction: Pharmacological blockage of glial activity has been proved useful for treatment of neuropathic pain by lowering proinflammatory cytokines. The present study is to confirm the effect of post-injury administration of pentoxifylline on chronic constriction injury (CCI)-induced neuropathic pain symptoms_ and improved the efficacy of morphine anti-nociception. Methods: Male Wistar ...
[ 22 ] - Analgesic effect of morphine microinjected into the nucleus raphe magnus after electrolytic lesion of nucleus cuneiformis in tail-flick and formalin tests in rat
Introduction: The antinociceptive effect of morphine is, in part, mediated through the activation of a descending pathway. One of the major components of this pathway is the nucleus raphe magnus (NRM). Our previous study demonstrated the involvement of NRM in the analgesic effect of morphine microinjected into the nucleus cuneiformis (NCF) in a descending manner. The aim of the current study...
[ 23 ] - Effect of nitric oxide on the attenuation of acquisition of morphine-induced conditioned place preference by the essential oil from Cuminum cyminum L. fruit in mice
Introduction: Nitric oxide (NO) is a neuronal messenger molecule in the central nervous system, which is generated from L-arginine by nitric oxide synthase (NOS) and involves in many important opioid-induced effects. Our previous studies revealed that Cuminum cyminum interestingly reduces morphine sensitization, tolerance and dependency in male mice. Therefore, in the present study, the effe...
[ 24 ] - Role of Orexin-A receptors within the Locus Coeruleus in the antinociception induced by microinjection of carbachol into the lateral hypothalamus
Introduction: Previous studies have shown that stimulation of lateral hypothalamus (LH) produces antinociception. Orexin-A (OXA) receptor is strongly expressed in the nucleus locus coeruleus (LC) and orexinergic fibers densely project from LH to LC. In this study, we assessed the role of LC and its OXA receptors in antinociceptive response induced by LH chemical stimulation in the rat. Meth...
[ 25 ] - The firing rate of neurons in the nucleus cuneiformis in response to formalin in male rat
Introduction: Although formalin-induced activity in primary afferent fibers and spinal dorsal horn is well described, the midbrain neural basis underlying each phase of behavior in formalin test has not been clarified. The present study was designed to investigate the nucleus cuneiformis (CnF) neuronal responses during two phases after subcutaneous injection of formalin into the hind paw...
[ 26 ] - اثر حفاظتی تمرین ورزشی تداومی و تناوبی بر کورتیکوسترون، وزن‌گیری و ناامیدی رفتاری در رت‌ها به‌دنبال یک دوره استرس مزمن غیرقابل‌پیش‌بینی
افسردگی یکی از شایع‌ترین اختلالات روانپزشکی است. احتمالاً انجام یک دوره تمرین ورزشی قبل از مقابله با شرایط استرس‌زا می‌تواند در کاهش علائم فیزیولوژیک و عملکردی افسردگی مؤثر باشد. با توجه به انواع روش‌های تمرین ورزشی، هدف این پژوهش بررسی اثر حفاظتی دو نوع تمرین تداومی و تناوبی شدید بر کورتیکوسترون، وزن‌گیری و ناامیدی رفتاری در رت‌ها به‌دنبال یک دوره استرس مزمن غیرقابل‌پیش‌بینی بود. تعداد 30 سر مو...
[ 27 ] - The Involvement of Intra-Hippocampal Dopamine Receptors in the Conditioned Place Preference Induced By Orexin Administration into the Rat Ventral Tegmental Area
The activity of dopamine (DA)-containing neurons in the ventral tegmental area (VTA) is a key mechanism in mesolimbic reward processing that has modulatory effects on different diencephalic structures like hippocampus (HIP), and receives inhibitory feedback and excitatory feed forward control. In addition, within the hippocampus, DA receptors are mostly located in the dorsal part (CA1) and dopa...
[ 28 ] - The Involvement of Intra-Hippocampal Dopamine Receptors in the Conditioned Place Preference Induced By Orexin Administration into the Rat Ventral Tegmental Area
The activity of dopamine (DA)-containing neurons in the ventral tegmental area (VTA) is a key mechanism in mesolimbic reward processing that has modulatory effects on different diencephalic structures like hippocampus (HIP), and receives inhibitory feedback and excitatory feed forward control. In addition, within the hippocampus, DA receptors are mostly located in the dorsal part (CA1) and dopa...
[ 29 ] - مقایسه اثرات تزریق مرفین و لیدوکائین در هسته میخی شکل موش صحرایی بر تعدیل حس درد مزمن و حاد با استفاده از آزمون فرمالین
Background and Aim: The cuneiformis nucleus (CnF), which rest in the ventrolateral portion of the periaqueductal gray matter, has opioid receptors that may modulate acute pain. The present study was conducted to evaluate the role of morphine injection into the area of rat’s brain CnF in the modulation of chronic pain and antinociceptive effect of morphine on this area. Materials and Methods: I...
[ 30 ] - Improving the Izhikevich Model Based on Rat Basolateral Amygdala and Hippocampus Neurons, and Recognizing Their Possible Firing Patterns
Introduction: Identifying the potential firing patterns following different brain regions under normal and abnormal conditions increases our understanding of events at the level of neural interactions in the brain. Furthermore, it is important to be capable of modeling the potential neural activities to build precise artificial neural networks. The Izhikevich model is one of the simplest biolog...
[ 31 ] - The Effect of Zinc and Vitamin D Nutrition on Reducing Morphine Side Effects and Development of Dental Anomalies in Rats Newborns
Introduction: The use of opioids such as morphine has anti-pain effects along with some side effects on body organs. Opioids such as morphine can be transferred from mother to child through the placenta and or breastfeeding. This study aimed to assess the effect of morphine on mineral content and histological changes of incisor teeth of rats born to morphine-addicted mothers. Methods: In this ...
[ 32 ] - Ventral Tegmental Area Microinjected-SKF38393 Increases Regular Chow Intake in 18 Hours Food Deprived Rats
Ventral tegmental area (VTA) dopamine neurons play an important role in reward mechanisms of food intake, and VTA dopamine receptors exist on the terminal of glutamatergic and GABAergic neurons and regulate GABA and glutamate release. To our knowledge, there is no evidence to show that VTA D1 dopamine receptors play a role in regular chow intake. In this paper, the effect of SKF38393, a D1 rece...
[ 33 ] - The Comparison of Working Memory and Reaction Time in Non-Athlete, Athlete and Heroin-Dependent Individuals *
Objective: The aim of this study was to compare memory working and semantic strop in non-athlete, athlete and heroin-dependent individuals. Method: The present study was a causal-comparative study. Forty-five men were selected by convenience sampling and divided into three groups: non-athlete, athlete, and heroin-dependent individuals. Participants were assessed using neuropsychological instrum...
[ 34 ] - Cannabidiol Modulating the Expression of Neurotrophin Signaling Pathways in Chronic Exposure to Methamphetamine in Rats During Abstinence Period
Introduction: Several neuropsychiatric disorders, such as addiction, have indicated variations in the levels of neurotrophic factors. As an extremely addictive stimulant, methamphetamine (METH) is associated with rising levels of abuse worldwide. We have recently demonstrated that repeated intracerebroventricular (ICV) of cannabidiol (CBD), the most important non-psychotomimetic compound, can l...
[ 35 ] - Differential Aspects of Natural and Morphine Reward-related Behaviors in Conditioned Place Preference Paradigm
Introduction: Natural rewards are essential for survival. However, drug-seeking behaviors can be maladaptive and endanger survival. The present study was conducted to enhance our understanding of how animals respond to food and morphine as natural and drug rewards, respectively, in a conditioned place preference (CPP) paradigm. Methods: We designed a protocol to induce food CPP and compare it ...
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