Mehdi Khaksari
Addiction Research Center, Shahroud University of Medical Sciences, Shahroud, Iran
[ 1 ] - Sulfur dioxide reduces hippocampal cells death and improves learning and memory deficits in rat model of transient global ischemia/reperfusion
Objective(s): According to recent the findings, sulfur dioxide (SO2) is produced by the cardiovascular system, influencing some major biological processes. Based on previous research, SO2 exhibits antioxidant effects and inhibits apoptosis following cardiac ischemia/reperfusion. Therefore, the objective of the current study was to examine the neuroprotective impact of SO2 following global cereb...
[ 2 ] - Neuroprotective effect of berberine chloride on cognitive impairment and hippocampal damage in experimental model of vascular dementia
Objective(s):The major objective of the present study was to investigate the potential neuroprotective effect of berberine chloride on vascular dementia. Berberine, as an ancient medicine in China and India, is the main active component derived from the Berberis sp. Several studies have revealed the beneficial effects of berberine in various neurodegenerative disorders. Materials and Methods: T...
[ 3 ] - اثر شرطی سازی اولیه با تمرین استقامتی بر اختلالات حافظه و مرگ سلولی نورون های ناحیه CA3 هیپوکامپ به دنبال ایسکمی- ریپرفیوژن مغزی در موش صحرایی نر
زمینه و هدف: ایسکمی مغزی موجب آسیبهای ساختاری و عملکردی برگشت ناپذیری در نواحی خاصی از مغز به ویژه هیپوکامپ خواهد شد. شواهد نشان میدهد که ورزش ممکن است آسیبهای ناشی از ایسکمی مغزی را کاهش دهد. هدف از این مطالعه بررسی اثر شرطی سازی اولیه با یک دوره تمرین ورزشی استقامتی بر اختلالات حافظه و مرگ سلولی نورونهای ناحیه CA3 هیپوکامپ به دنبال ایسکمی- جریان مجدد مغزی در موش صحرایی نر بود. روش...
[ 4 ] - اثر شیرابه زرد رنگ گیاه آلوئه ورا و عصاره الکلی بره موم بر بهبود زخم در موش های صحرائی دیابتی
مقدمه: زخم و عوارض ناشی از آن می تواند مشکلات زیادی را برای بیماران به وجود آورد. لذا شناخت عواملی که بتوانند در درمان زخم موثر باشند و از گسترش آسیب ها جلوگیری کنند حائز اهمیت است. بنا بر این مطالعه حاضر با هدف شناسایی عوامل موثر بر ترمیم زخم از شیرابه زرد رنگ گیاه آلوئه ورا و عصاره الکلی بره موم مورد بررسی قرار گرفته است. مواد و روش ها: در این تحقیق 50 سر موش صحرایی نژاد ویستار(180-130گرم...
[ 5 ] - Obestatin inhibits apoptosis and astrogliosis of hippocampal neurons following global cerebral ischemia reperfusion via antioxidant and anti-inflammatory mechanisms
Objective(s): Obestatin is a newly discovered peptide with antioxidant activities in different animal models. Recent studies have shown that Obestatin inhibits apoptosis following cardiac ischemia/reperfusion injury. Brain ischemia/reperfusion induces irreversible damage especially in the hippocampus area. This study aimed at examining the protective impact of Obestati...
[ 6 ] - Protective Effects of Nucleobinding-2 After Cerebral Ischemia Via Modulating Bcl-2/Bax Ratio and Reducing Glial Fibrillary Acid Protein Expression
Introduction: Nucleobinding-2 (NUCB2) or nesfatin-1, a newly identified anorexigenic peptide, has antioxidant, anti-inflammatory, and anti-apoptotic properties. Brain ischemia-reperfusion induces irreversible damages, especially in the hippocampus area. However, the therapeutic effects of NUCB2 have not been well investigated in cerebral ischemia. This study was designed for the first time to i...
[ 7 ] - Usnic acid improves memory impairment after cerebral ischemia/reperfusion injuries by anti-neuroinflammatory, anti-oxidant, and anti-apoptotic properties
Objective(s): Cerebral ischemia/reperfusion causes complex pathological mechanisms that lead to brain tissue damage. Usnic acid is a lichen secondary metabolite that has many different biological properties including anti-inflammatory and anti-oxidant activities. Therefore, the objective of the current study was to investigate the neuroprotective effects of usnic acid ...
[ 8 ] - Effects of Usnic Acid on Apoptosis and Expression of Bax and Bcl-2 Proteins in Hippocampal CA1 Neurons Following Cerebral Ischemia-Reperfusion
Introduction: Cerebral ischemia-reperfusion causes complex pathological mechanisms that lead to tissue damage, such as neuronal apoptosis. Usnic acid is a secondary metabolite of lichen and has various biological properties including antioxidant and anti-inflammatory activities. This study aimed to investigate the neuroprotective effects of usnic acid on apoptotic cell death and apoptotic-relat...
[ 9 ] - Effect of simvastatin on memory disorders and Hippocampal cell death in the model of the fetal alcoholic syndrome in male rats
Introduction: Exposure to ethanol as a neurotratogen in the developmental period has destructive effects on the central nervous system and causes neurological disorders in adulthood. These disorders are associated with apoptosis in areas of the brain such as the hippocampus, by activating the oxidative-inflammatory cascade and high levels of nerve degeneration. Simvastatin, used as a drug to tr...
نویسندگان همکار