Seyedeh Azam Hosseini
Psychiatry and Behavioral Sciences Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
[ 1 ] - Comparative Study on the Effect of Risperidone and its Combination with Naltrexone in Pediatric Patients with Autistic Spectrum Disorders: A Clinical Trial Study
Background Autistic spectrum disorder (ASD) refers to a syndrome associated with persistent impairments in communication skills, social interactions, and so forth. Given the approval of risperidone and naltrexone by U.S. Food and Drug Administration (FDA) for ASD cases and extant controversy concerning their pertained side effects, this double-blind, placebo-controlled, crossover clinical trial...
[ 2 ] - Combination of Nigella sativa with Glycyrrhiza glabra and Zingiber officinale augments their protective effects on doxorubicin-induced toxicity in h9c2 cells
Objective(s):The use of doxorubicin (DOX) is limited by its dose-dependent cardio toxicity in which reactive Oxygen Species (ROS) play an important role in the pathological process. The aim of this study was to evaluate the protective effect of three medicinal plants, Nigella sativa (N), Glycyrrhiza glabra (G) and Zingiber officinale (Z), and their combination (NGZ), against DOX-induced apoptos...
[ 3 ] - Differential Metabolic Effects of Novel Cilostamide Analogs, Methyl Carbostiryl Derivatives, on Mouse and Hyperglycemic Rat
Objective(s) PDE3 has a functional role in insulin secretion and action. We investigated the metabolic effects of new synthetic PDE3 inhibitors (mc1, mc2, mc5 and mc6), on mice and hyperglycemic rat. Materials and Methods The test compound or solvent was injected subcutaneously to mice, for 7 days. On day 8, blood and liver samples were obtained. In hyperglycemic rat, 0.5 g/kg glucose with o...
[ 4 ] - اثر عصاره آبی الکلی بارهنگ بر زخم معده ناشی از ایندومتاسین در موش صحرایی
اهداف: گیاه بارهنگ در طب سنتی برای درمان اختلالات گوارشی استفاده می شود، هدف این مطالعه تعیین اثر عصاره آبی الکلی بارهنگ بر زخم معده ناشی از ایندومتاسین بود. مواد و روش ها: در این مطالعه تجربی از 72 سر موش صحرایی نر نژاد ویستار استفاده گردید. در گروههای درمانی، ابتدا با گاواژ ایندومتاسین (mg/kg 35)، زخم معده القا گردید و سپس به مدت 3 روز، به حیوانات، رانیتیدین (mg/kg 50) و دوزهای مختلف عصاره ب...
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