Tracheal overexpression of IL-1β, IRAK-1 and TRAF-6 mRNA in obese-asthmatic male Wistar rats

نویسندگان

  • Amir Mehdi Khamaneh School of Advanced Medical Sciences, Tabriz University of Medical Sciences, Tabriz, Iran
  • Maryam Fallahi Department of Physiology, Tabriz University of Medical Sciences, Tabriz, Iran
  • Mehran Mesgari Abbasi Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
  • Mohammad Reza Alipour Tuberculosis and Lung Diseases Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
  • Mohammad Reza Aslani Tuberculosis and Lung Diseases Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
  • Rana Keyhanmanesh Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
چکیده مقاله:

Objective(s): Human and animal studies have shown a close relationship between obesity and asthma severity. Here, we examined the effects of diet-induced obesity (DIO) on the expression levels of IL-1β, IRAK-1 and TRAF-6 mRNA in male Wistar rats tracheal after sensitization with ovalbumin (OVA). Materials and Methods:Twenty male Wistar rats divided to four groups, included, control group with normal diet (C+ND), OVA-sensitized group with normal diet (S+ND), control group with high-fat diet (C+HFD), and OVA-sensitized group with high-fat diet (S+HFD). All animals fed for 8 weeks with standard pelts or high-fat diet, and then were sensitized and challenged with OVA or saline for another 4 weeks with designed regimens. At the end of study, trachea isolated and examined for expression levels of IL-1β, IRAK-1 and TRAF-6 mRNA with RT-PCR method. Results:Diet-induced obesity groups developed increased weight, obesity indexes and lipid profiles (P

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tracheal overexpression of il-1β, irak-1 and traf-6 mrna in obese-asthmatic male wistar rats

objective(s): human and animal studies have shown a close relationship between obesity and asthma severity. here, we examined the effects of diet-induced obesity (dio) on the expression levels of il-1β, irak-1 and traf-6 mrna in male wistar rats tracheal after sensitization with ovalbumin (ova). materials and methods:twenty male wistar rats divided to four groups, included, control group with n...

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عنوان ژورنال

دوره 19  شماره 4

صفحات  350- 357

تاریخ انتشار 2016-04-01

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