The Protective Effects of Allium Saralicum Aqueous Extract on Blood Glucose and Some Related Biochemical Factors in Alloxan-Induced Diabetic Male Rats: An Experimental Study

Background and Objectives: Diabetes is one of the most common metabolic disorders. Medicinal plants have been used for controlling diabetes. The aim of the present study was to investigate the protective effect of Allium saralicum on blood glucose and some related biochemical factors in alloxan induced type-1 diabetes in male rats. Materials and Methods: In this experimental study, diabetes was induced by single-dose intraperitoneal injection of alloxan (120 mg/kg/bw). Thirty male rats weighing 200±20 g were divided into 6 groups of 5. Group 1 (normal control), Group 2 (diabetic control), Group 3 (diabetic group receiving glibenclamide (20 mg/kg/bw), Groups 4 to 6 including diabetic groups receiving aqueous extract of Allium saralicum (20, 60 and 180 mg/kg/bw), respectively by gavage for 25 days. At the end of the treatment period, blood samples were collected and serum levels of glucose, alkaline phosphatase, alanine aminotransferase, aspartate aminotransferase, lactate dehydrogenase, urea, and creatinine were evaluated. Data were analyzed using one-way analysis of variance and Duncan’s post hoc tests. Results: The results indicated that Allium saralicum extract improved body weight loss in the diabetic group (p<0.05). Also, serum levels of glucose, alkaline phosphatase, alanine aminotransferase, aspartate aminotransferase, lactate dehydrogenase, urea, and creatinine in the diabetic group were higher than those in the control group (p<0.05). These changes were ameliorated by treatment with Allium saralicum extract at different doses similar to glibenclamide (p<0.05). Conclusion: Allium saralicum extract may have a protective effect against blood glucose and some biochemical factors alterations caused by alloxan-induced diabetes. Key words: Allium saralicum Aqueous Extract, Alloxan, Diabetes, Rat Funding: This study was funded by Razi University, Kermanshah, Iran. Conflict of interest: None declared. Ethical approval: The Ethics Committee of Razi University approved the study (Ethic Nubmer: 396-2-037). How to cite this article: Bahrami Erfan, Pooyanmehr Mehrdad, Maleki Ali, Alimohammadi Samad.The Protective Effects of Allium Saralicum Aqueous Extract on Blood Glucose and Some Related Biochemical Factors in Alloxan-Induced Diabetic Male Rats: An Experimental Study. J Rafsanjan Univ Med Sci 2022; 21 (07): 728-40. [Farsi]