THE MALONDIALDEHYDE LEVEL AND ITS PREDICTION ROLE IN PRETERM DELIVERY AND ABORTION

Background & Aims: Increased energy demand and oxygen consumption lead to oxidative stress by free oxygen species. Various factors can predispose mothers to oxidative stress in pregnancy. Therefore, this study aimed to assess the relationship between premature birth and serum MDA (a marker of oxidative stress) during pregnancy. Materials & Methods: This analytical (case-control) study was conducted on 43 pregnant women in Qaen- Khorasan. Based on health records, the blood sample of the individuals with history of abortion, stillbirth or preterm were taken. The level of MDA was measured by ELISA and was compared with normal pregnant women. Results: In this study, the mean MDA was significantly higher in woman with risk factor (13.82) compared to women without risk factor (8.39) (p=0.001). Also, the level of MDA in woman with a history of abortion (14.31) was higher in comparison to women with preterm delivery (13.). Conclusion: These results showed that oxidative stress and the level of MDA can be considered as a risk factor for preterm delivery.