The Exogenous Estrogen Antiproliferaive Effects On Cervical Cancer Cell Line: An In Vitro Study

Estradiol valerate (Exogenous estrogen) is a synthetic ester and is also a female estrogen hormone. There arestudies showing that estradiol may have anticancer effects. This study was performed to reveal the effects ofexogenous estrogens on the viability of cervical cancer cells in cell culture. We used Hela cells as our cell linein this study. Hela cells were exposed to 0.0001, 0.001, 0.01, 0.1, 1 and 10 mg/ml of estradiol. Control Helacells were not exposed to estradiol. MTT assay was used to determine the viability of cervical cancer cells incell culture. Results indicated that administration of 10 mg/ml Estradiol led to significant decrease in viabilityof Hela cells compared to control cells (P