The effects of eight weeks resistance training on α -1A protein of pre-synaptic P-Q-type calcium channels in FHL and soleus muscles of rats

The purpose of this study was to investigate the effects of 8 weeks resistance training (RT) on α -1A protein of pre-synaptic P-Q-type Calcium Channels in FHL and soleus muscles of rats. 16 male wistar rats provided from razi institute, randomly divided to 2 groups (Control-Sham; n=8 and Resistance Training; n= 8). Training group conducted 8 weeks (5 session/week) resistance program on special 1 meter height ladder (divided by 26 stairs) with loading 30% body weight (suspended from the tail) in the first week and increased to 200% BW in the last week. Training includes 3 set of 4 reps. with 3 min. rest between sets. Measuring α -1A protein with Western Blotting and independent T test showed that the amount of this protein insignificantly increased in FHL muscles of RT group (FHL: 77.88±10.67 vs. Control: 70.01± 6.28 and soleus: 72.71±19.72 vs. Control: 72.57 ± 20.20). This insignificant increase in α -1A protein in FHL, can shows an responsiveness of pre-synaptic P-Q-type Calcium Channels of muscles following resistance training for improving Ach release from presynaptic terminal, noted in NMJ adaptations . In conclusion, we can express that probably resistance training can be a main factor for α -1A protein improving in muscles and this case should be study in future investigations with high volume and intensities training