The effect of resistance training on the expression of cardiac muscle growth regulator messenger genes in obese male rats

Background: Obesity is associated with cardiovascular disease, followed by pathological cardiac hypertrophy. However, physical activity (resistance training) plays a role in modulating some of the intracellular messenger pathways associated with the regulation of pathologic hypertrophy. The aim of this study was to investigate The effect of resistance training on the expression of cardiac muscle growth regulator messenger genes in obese male rats. Material and Methods:  In this experimental study, 18 male Sprague Dawley rats were divided into 3 groups; healthy control (n=6) and obesity control (n = 6) and resistance training (n = 6) after eight weeks of using high fat diet. Total resistance training was performed for a total of eight weeks. 48 hours after completion of the curcumin supplement protocol, the rats were dissected and their heart muscle removed. The expression of genes (AMPK, mTOR, S6K, 4EBP, COL1, COL3, AngII) was calculated using Real Time-PCR technique and the 2-∆∆CTmethod. One way ANOVA was used to determine the significance of the variables among the study groups. Results: The results showed that the resistance training group compared to the control group showed an increase in expression of mTOR (P = 0.068), 4EBP (P = 0.054), which was not statistically significant. On the other hand, expression of S6K (P = 0.002) AMPK (P = 0.008) increased significantly. Also, there was a decrease in the expression of collagen 1 (P = 0.225), collagen 3 (p = 0.044) Ang II (p = 0.104) and differences were statistically significant. Conclusion: Muscle obesity seems to cause cardiac pathological hypertrophy and accelerate the process of heart aging, but resistance training, which is an appropriate replacement, has somewhat reduced the negative effects of obesity on cardiac function in the cardiac aging process. that replaces the proper and partly negative effects of obesity on cardiac function in the process of heart aging has been reduced.