The effect of resistance training on protein-D surfactant and insulin resistance index in healthy and type 2 diabetic rats

Introduction Protein-D Surfactant (SPD) is a new factor associated with glucose intolerance, insulin resistance, and type 2 diabetes. The aim of the present study was to investigate the effects of resistance training on surfactant protein-D in streptozotocin-nicotinamide-induced diabetic rats. Materials and Methods In this experimental study، 48 adult male Wistar rats in the weight range of 200±48gr, randomly assigned into four groups: healthy control, diabetic control, diabetic resistance training, and healthy resistance training. For induction of diabetes, intraperitoneal injection of nicotinamide solution and STZ solution was used. The training groups performed a resistance training program for 10 weeks. Data were analyzed using one-way ANOVA and Tuky  Post-hoc test at 0.05%. Results Resistance training caused a significant decrease in blood glucose in the resistance diabetic training group compared to the diabetic control group (P=0.024). Serum Protein-D Surfactant (SPD) serum levels in the diabetic control group significantly decreased (P=0.042) and the insulin resistance index (P=0.024) was significantly lower than healthy controls. 8 weeks of endurance training significantly increased in SPD in endurance diabetic training group compared to diabetic control group (P=0.043). Also, exercise significantly decreased insulin resistance index (P=0.034) and insulin in endurance diabetic training group compared to diabetic control group (P=0.046). Conclusion The results of this study seem to confirm the role of Protein-D Surfactant associated with resistance training in improving insulin resistance index in type 2 diabetic rats.