The effect of resistance training on malondialdehyde and protein carbonyl concentration in the heart tissue of rats exposed to stanozolol

Introduction: Consumption of anabolic steroids causes damage to various tissues, including the heart. The aim of this study was to investigate the effect of resistance training (RT) on malondialdehyde (MDA) and protein carbonyl (PC) in the heart tissue of rats exposed to stanozolol (S). Methods: In this experimental study, 18 rats with mean age of 8 weeks and weight range of 150 to 200 g were selected and divided into three groups of 6 rats, including 1) sham (normal saline consumption) (Sh), 2) S, and 3) S + RT. For eight weeks, the S and S + RT groups received 5 mg/kg/day S and the S + RT group performed five RT sessions per week. Measurement of MDA and PC in the heart tissue was performed by ELISA. Results: Stanozolol had a significant effect on increasing MAD (P=0.001) and PC (P=0.03) in the heart tissue. However, RT led to a decrease in MDA and PC in in the heart tissue of rats exposed to S (P=0.001). Conclusion: It appears that S consumption leads to an increase in MDA and PC levels in the heart tissue, while RT can improve elevated levels of MDA and PC.