The Effect of Metoclopramide on Elimination of Nausea Reflex During Impression Making

Abstract Background and aim: Nausea reflex during impression-taking is a concern that decreases the patient's ability to accept dental procedures. There are several methods for elimination of nausea reflex, Prescription of Metoclopramide is one of these pharmaceutical methods. The aim of this study is to evaluate effect of Metoclopramide on the elimination of nausea reflex during impression-taking in patients referring to Prosthodontics Department of the Faculty of Dentistry Tehran Medical Sciences, Islamic Azad University in 2018-19. Materials and Methods: This research is a clinical trial study (before and after study) which was performed on patients referring to fix Prosthodontics department, faculty of Dentistry. Patients should have no medical problem, without any history of drug or any other type of allergy. Only patients with a nausea reflex VAS benchmark over 5, were included in this study. The patients were asked not to eat since 3 hours before impression-taking. Then the nausea reflex intensity before pharmaceutical treatment recorded. Afterwards, 1 ml (25 drops) of Metoclopramide hydrochloride along with 1 mg of sodium saccharin (as a sweetener) was prescribed. After half an hour, the intensity of the nausea reflex was measured again by the same VAS system, and the amount of change in the nausea reflex intensity was investigated by McNemar's statistical test in SPSS V25 software. Results: The study was performed on 28 eligible individuals, 46.4% male and 53.7% women, and 25-56 years old, all of whom had a nausea reflex VAS of more than 5, while after using Metoclopramide, all patients (100%) reported nausea reflex score of 5 or less (P <0.0001). The reflex intensity before and after pharmaceutical treatment was 9/7 ± 3/3 and 3.1± 1.4, respectively. Conclusion: It seems that prescription of Metoclopramide can eliminate nausea reflex intensity during impression-taking in dental patients.