The effect of high-intensity interval training (HIIT) and quercetin supplementation on dimension and functional left ventricular adaptations in men with hypertension and CAD after PCI

Objective: The present study investigated the effects of 10-week High Intensity Interval Training (HIIT) and quercetin consumption on dimension and functional left ventricular adaptations in men with hypertension and coronary artery disease (CAD) after percutaneous coronary intervention (PCI).   Materials and Methods: In this semi-experimental randomized, placebo‑controlled and double‑blind study, 34 men with hypertension and CAD after PCI aged 40-60 years were randomly divided into 3 groups of quercetin (n=11), HIIT+quercetin (n=12) and HIIT+placebo (n=11), were followed for 8 weeks of HIIT (30 seconds of activity and 30 seconds of rest) and quercetin consumption (250 mg of quercetin supplement or placebo pills daily). Echocardiography was used to investigate morphological factors such as Left Ventricle Diastolic Diameter (LVDD), Left Ventricle Systolic Diameter (LVSD), Ejection Fraction (EF) and left ventricular diastolic function(E/A). Data were analyzed using paired t test and one way ANOVA at a significant level of 0.05.   Results: Systolic and diastolic Left Ventricular Dimensions (LVDs and LVDd) increased in the HIIT+quercetin (p<0.05) and Left ventricular systolic and diastolic function increased in the HIIT+quercetin and in the HIIT+ placebo and quercetin group (p<0.05) with no significant difference between the groups regarding these variables (p>0.05).   Conclusion: HIIT with quercetin supplementation can improve the dimensions and function of the left ventricle in men with hypertension and CAD after PCI, whereas separate use of exercise and quercetin increases ventricular function without affecting the dimensions of the left ventricle.