The effect of hepatic protection of hydro alcoholic extract of Thyme in rats (Thymus daenensis).

Background  Thyme has high antioxidant properties due to polyphenols and flavonoids. The aim of this study was to evaluate the effects of hepatic protection of Thyme on the toxicity induced by carbon tetrachloride in rats. Materials and methods In this experimental study, 40 male Wistar rats weighing 220-250 grams were randomly divided into five groups of eight. One group was monitored and four other groups, hepatotoxic was included by carbon tetrachloride. From these four groups, one is a control group and three other groups per day respectively 400,600 and 800(mg) were given oral powder. At 45 days after the start of the study, all groups received alanine, amino transferee enzymes (ALT), aspartate amino transferee (AST) and Alkaline phosphatase (ALP), as well as serum total protein, albumin and bilirubin concentrations, which are indicators of liver injury, were analyzed by ANOVA test. Results There are no significant difference in total protein, total albumin and total bilirubin concentration in negative control group compared to positive control group. The activity of liver enzymes in the (0.05) of activity of liver enzymes was significantly different test group ll and bilirubin in the test group III showed a better decrease. Conclusion The result of this study shows that the extracts of Thyme in comparison with the liver injuries caused by carbon tetrachloride have protective effects.