The effect of endurance training[a1] on Change of MYH7 and MYH7b genes expression and left ventricular structural changes of wistar male rats

Abstract Background; the MYH7 and MYH7b genes have important role on heart function on other hand endurance training is a challenge for heart function, therefore the aim this study was to study The effect of endurance training[a2]  on Change of MYH7and MYH7b genes expression and left ventricular structural changes of wistar male rats.   Material and Methods; For this purpose, 14 rats (113±20 gram) under controlled conditions (temperature, light/dark (12:12) cycle, with ad Libitum access to food and water) were housed, after familiarization (231±24) there were randomly assigned into control (n=7) and Experimental (n=7) groups, the experimental group performed one training program (30 m/min, 50 min, 6 session per week for 14-weeks) on motorized treadmill, and then 48 hours after the end of the last session with control group were anesthetized and sacrificed, then the left ventricle of the heart was removed. Real time RT-PCR method was used to determine of expression levels of MYH7 and MYH7b genes, finally to compare of control and experimental groups means t-test was use. Results; endurance training significantly induced increase in ratio of heart weight to body weight in experimental group in compare with control group(p=0.005), also it was seen the increasing significantly in expression MYH7 and MYH7b genes in experimental group than control group(p=.001). Conclusion; It seems the endurance training induce remodeling which showed by hypertrophy and it coincided with increasing of MYH7 and MYH7b genes expression. Keyword: MYH7 and MYH7b genes, endurance activity, heart, left ventricle