The Effect of Eight Weeks of Intermittent Training with Quercetin Encapsulated Nanoparticles on JNK and ERK Apoptosis Regulators in the Rat Model of Myocardial Infarction

Introduction: Restoration of blood flow to the ischemic heart muscle causes infarction and myocyte death. Quercetin can be effective in treating heart disease due to its antioxidant effect, but its use is limited due to its low solubility in water. Quercetin restriction can be removed by embedding it in carrier nanoparticles. The present study was designed to determine the effect of quercetin encapsulated nanoparticles(QEN) with intermittent exercise on the expression of JNK and ERK genes. Materials and Methods: Thirty rats were randomly divided into five groups (healthy, myocardial infarction, myocardial infarction and supplement, myocardial infarction and exercise, myocardial infarction and exercise and supplement). Myocardial infarction was performed with isoprenaline in 24 rats by subcutaneous injection. In the supplement groups, supplemental gavage was performed after each training session. Cardiac tissue isolation was performed 48 hours after the last training session. Real-Time PCR measured the relative expression of JNK and ERK genes. Data analysis was performed by one-way analysis of variance at a significant level of 0.05. Results: The expression of JNK and ERK genes was significantly reduced in the exercise and supplementation group compared to the myocardial infarction group. Conclusion: Taking QEN with periodic aerobic exercise can reduce the expression of JNK and ERK genes, which reducing the expression of JNK and ERK genes, it can reduce the activation of the JNK and ERK complex and thus reduce cell death through apoptosis and therefore have a protective effect on cardiac myocytes following ischemic injury.