The Effect of Eight weeks High Intensity Interval Training Along with Portulaca Oleracea Consumption on Lipid Profile of Rats with Non-Alcoholic Fatty Liver

Aims: Lifestyle changes including physical activity and nutrition are very important factors in controlling non-alcoholic fatty liver disease. Therefore, the aim of the present research was to investigate the effect of eight weeks of high intensity interval training with portulaca oleracea supplementation on the lipid profile of rats with non-alcoholic fatty liver. Methods and Materials: For this propose 25 male Wistar rats randomly divided into five groups: healthy control, fatty liver control, and Portulaca Oleracea supplement, high intensity interval training and high intensity interval training + Portulaca Oleracea supplement. To induce non-alcoholic fatty liver, rats were fed a high-fat diet for 12 weeks. The interval training training protocol was performed for eight weeks, five sessions per week. Plasma High Density Lipoprotein, Low Density Lipoprotein, Triglyceride and total cholesterol levels were measured. One way ANOVA and tukey post-hoc test was used to analyze the data and P<0.05 was considered significant. Findings: Plasma Triglyceride levels in the high intensity interval training +supplement group were significantly lower than the fatty liver control group (p=0.035). Total cholesterol level in supplement group (p=0.013) and high intensity interval training +supplement (p=0.001) was significantly lower than fatty liver control group, but There was no significant difference between plasma TC levels in high intensity interval training group and fatty liver control (p=0.229). Plasma High Density Lipoprotein level in high intensity interval training + supplement group compared to healthy control (p=0.021), fatty liver control (p =0.001), high intensity interval training (p=0.006) and portulaca oleracea supplement (p=0.018). Plasma Low Density Lipoprotein levels in the high intensity interval training group (p =0.01), supplementat (p=0.001) and high intensity interval training +supplement (p=0.001) were significantly lower than the fatty liver control group. Conclusion: It seems that combining high intensity interval training with portulaca oleracea supplementation can have better results than exercise and supplementation alone, therefore this method can be used as a complementary therapy in people with non-alcoholic fatty liver.