The Effect of Circular Training Program on Endothelial-Derived Microparticles in Overweight Men

Objective: Aging is associated with endothelial dysfunction and arthrosclerosis. This study aimed to assesses the impact of combined circular training (resistance-interval) on endothelial-derived microparticles (EMPs) as a marker of endothelial function and cardiovascular risk factors in overweight elderly men. Materials and Methods: In this experimental study, twenty four overweight men aged 50 - 55 years were divided to exercise group (8 weeks circular training, 3 times/weekly, n= 12) and control group (no training, n= 12) by simple random sampling. The anthropometric measurements, serum EMPs and cardiovascular risk factors (triglyceride (TG), total cholesterol (TC), low density lipoprotein (LDL), and high density lipoprotein (HDL)) were measured before and after training program in exercise and control groups. Data were analyzed by student’s T-test to assess the statistical significance of the changes. P-value less than 0.05 were considered statistically significant. Results: A significant decreases were observed in anthropometrical markers (weight, BMI, body fat percentage) by training program in exercise group (P-value< 0.001). Circular training induced significant decrease in EMPs (P-value= 0.004), TG (P-value= 0.020), TC (P-value= 0.001) and increase in HDL (P-value< 0.001) compared to pre-training. No significant change was observed in LDL by circular training in exercise group (P-value= 0.052). There were no changes in all dependent variables in the control subjects (P-value≥ 0.05). Conclusion: Based on these data, it is concluded that combined circular training can be improve endothelial function in overweight elderly men.