The Effect of Cardio Gel and Matrigel on the Ultrastructure of Cardiomyocytes Derived From Mouse Embryonic Stem Cells

Purpose: To investigate the effect of cardiogel and matrigel on the ultrastructure of embryonic stem cell-derived cardiomyocytes. ECM: Extracellular Matrix derived from cardiac fibroblasts (cardiogel), commercial extracellular matrix (matrigel) and control group (without ECM) were cultured for up to 21 days. Ultrastructural properties of cardiomyocytes were evaluated by transmitting electron microscopy (TEM). On the fourteenth day in cardiomyocytes showed cardiogel and on the twenty-first day of culture in all groups, the above structures appeared. Conclusion: The results of this study showed that it is possible to produce mature cardiomyocytes (ultrastructurally) from stem cells Embryonic and fibroblast-derived cardiogels are effective in the faster maturation of embryonic stem cell-derived cardiomyocytes.