The Cytotoxic Effects of Eggplant Peel Extract on Human Gastric Adenocarcinoma Cells and Normal Cells

Background and objective: Gastric cancer is the fourth common and the second deadliest cancer worldwide, which the major causes of its prevalence are genetic factors and the lifestyle, such as eating fast foods, physical inactivity, environmental pollution, and other natural factors. Method: This research was performed in human and animal cell bank of Iranian Biological Resource Center, and cytotoxic effects of the eggplant peel extract was investigated on human gastric cancer cells and normal cells. During this experiment, all quality control procedures were performed on cell lines, including bacteria, fungi, yeasts, molds, mycoplasma, as well as HIV-I, HBV, HCV, EBV viruses, and the results of negative tests were reported. MTT test was used to determine the cytotoxicity of this substance and the IC50 value. Resutls: The results indicated that the toxic effect of eggplant extract was more on the cancer cells compared to the normal cells and it is notable that, the death rate of the cancer cells in three concentrations showed a significant difference compared to the normal cells.  Conclusion: From the results of this study, it is recommended that further investigations be conducted on eggplant extract as an anticancer nutrient.