Study the Relationship Between some Physiological Biomarkers in men suffering from obesity and the Risk of Metabolic Syndrome

     This study aimed to estimate the levels of some biomarkers such as PON-1, PAI-1, OX-LDL, and ET-1 in the blood plasma of obese men and to study their relationship as risk predictors of metabolic syndrome.      Method and result: The study involved the collection of 88 blood serum samples from men who have metabolic health, including 28 samples from normal weights, whose body mass index (BMI) values ranged between 18.5-24.5 kg/m2 and whose waist circumference (WC) was less than 102 cm, As a control group. and 60 samples of men suffering from obesity were divided according to BMI and WC into two groups. The first group had BMI values ranging between 35-40 kg/m2 and a WC of 110-125 cm. While the second group had values of body BMI greater than 40 kg / m2 and a WC greater than 125 cm. the results showed that there was a significant decrease at the probability P≤0.01 in the concentration of PON-1 enzyme in the obese group. While PAI-1 was significantly higher in the obese group compared to the normal weight . Also, there were no significant differences in the concentration of OX-LDL and ET-1 between the two groups. It was found that there was a significant increase in the levels of PAI-1 and ET-1 in the BMI>40 group compared to the         40 ≥BMI≥35 group. Also, there were no significant differences in the concentrations of all biomarkers between the two waist circumference groups .