Response of Pancreatic AKT1 Gene Expression, Insulin and Glycemic Indices to the Aerobic Training Period in Type 2 Diabetes Wistar Rats

Objective: Laboratory studies on diabetic rats have shown that diabetic rats have a lower beta cell mass than healthy rats. On the other hand, over the years, with tremendous advances in genetic science, many studies have been done on the expression of genes and its effective factors, such as physical activity. One of these genes is AKT / PKB. Due to the association between the expression of this gene and type 2 diabetes, the effect of physical activity on the expression of this gene seems to be necessary. Materials and Methods: 30 male Wistar 10 week olds were randomly divided into three groups: healthy control, diabetic control and diabetic training. The diabetic control group was diabetic and injected with nicotinic amide and streptozotocin. The diabetic group was trained for 12 weeks Aerobic on the treadmill. Results: Based on independent t-test, aerobic training showed a significant increase in the relative expression of AKT / PKB in the pancreatic tissue of the aerobic diabetic group compared to the diabetic control group. Conclusion: The AKT / PKB signaling pathway not only plays an important role in insulin resistance, but also plays an important role in the ability of beta cells to adapt to increased insulin levels. Therefore, it can be concluded that environmental factors such as aerobic activity. The expression of the AKT / PKB gene expression can be effective in improving the treatment of type 2 diabetes.