P-82: The Role of Toll-Like Receptor 2 in Ectopic Pregnancy
نویسندگان
چکیده مقاله:
Background: The innate immune system is our first line of defense against invading pathogens. Toll–like receptors (TLRs) have been identified as a key role in mediating the function of innate immune system which bridges the gap between innate and adaptive immunity. For example, TLR2 is able to act as a homodimer to recognize lipoteichoic acids of Gram-positive bacteria but as a heterodimer with TLR1 or TLR6 to recognize triacylated lipoproteins and diacylated lipoproteins, respectively. Functional roles of TLR in the female reproductive tract health are important and will elucidate the complexity of immunological events impacting on pregnancy. Ectopic Pregnancy (EP) is a pregnancy where the fertilized egg implants outside the uterus and it often occurs in the Fallopian Tube (FT). Thus, the objective of this study is investigation TLR2 expression in FTs carrying EP. Materials and Methods: Biopsies from Infundibulum, Ampulla and Isthmus of FT were obtained from women who underwent hysterectomy and salpingectomy for EP. Human chorionic gonadotropin (HCG) was injected in 14 days leading up to hysterectomy to produce a state of pseudo-pregnancy. In this study pseudo-pregnants are control group and ectopic pregnants are case group. RT-PCR was used to test the existence of TLR2 gene in these sections. FT from pseudo-pregnants and ectopic pregnants were compared with Q-PCR for TLR2 gene. Results: By using RT-PCR, TLR2 expression has found in Infundibulum, Ampulla and Isthmus from case and control group. Q-PCR has shown relative TLR2 expression in all parts of FT from control group is stronger than case group. Conclusion: Besides TLRs role in protection against invading microorganisms in the female reproductive tract, growing evidence suggests an important role for TLRs in mediating several interactions occurring between the immune and reproductive system. It is likely that turning down of TLR2 expression in FT can predispose to ectopic pregnancy.
منابع مشابه
P-33: Expression of Toll-Like Receptor 2-3 Genes in Human Sertoli Cells
Background: Toll-like receptors (TLRs) constitute a major part of innate immunity, which can distinguish pathogen associate molecular pattern. Sertoli cells create a special immunological niche that protects somniferous tubules from auto antigens and pathogens. These cells are the only somatic cells in somniferous that protect testis cells against pathogens. The purpose of this study was to eva...
متن کاملP-189: Gene Variations of Toll-Like Receptor 2 in Endometriosis
Background: Endometriosis, a common, benign, estrogendependent and chronic inflammatory condition, is characterized by the ectopic growth of endometrial tissue that is found primarily in the peritoneum, ovaries and rectovaginal septum. In addition to its usual description as a hormonal disorder, some genetic, immunological and environmental factors can affect this disease. Toll-like receptors (...
متن کاملP-184: The Role of Cell Surface Toll Like Receptors in Endometriosis
Background: Toll like receptors (TLRs) are a major family of innate immune systems which recognize specific pathogen associated molecular patterns (PAMPS)in bacterial, fungi, virus and parasites. Human TLRs comprise a large family of 10 different type proteins that are expressed on various immune cells. Among these receptors, TLR1, 2, 4, 5, 6 and 10 were expressed on the cell surface. TLR2 form...
متن کاملP-225: Gene Variations of Toll-Like Receptor 3 in Endometriosis
Background: Endometriosis is a common gynecologic disorder that is characterized by the ectopic growth of endometrial tissue. Recently, endometriosis has been alternatively described as an immune, genetic and hormonal disease caused by exposure to environmental factors. Toll-like receptor 3 (TLR3) comprises a family of receptors through directly recognizing exogenous and endogenous ligands play...
متن کاملمنابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ذخیره در منابع من قبلا به منابع من ذحیره شده{@ msg_add @}
عنوان ژورنال
دوره 5 شماره Supplement Issue
صفحات -
تاریخ انتشار 2011-09-01
با دنبال کردن یک ژورنال هنگامی که شماره جدید این ژورنال منتشر می شود به شما از طریق ایمیل اطلاع داده می شود.
کلمات کلیدی
میزبانی شده توسط پلتفرم ابری doprax.com
copyright © 2015-2023