P-79: The Study of Levofloxacin Antibiotic Effects on Male Sexual Hormone in Wistar Rat

Background: Levofloxacinis a fluoroquinolone antibacterial agent with a broad spectrum of activity against different infectious disease and Gram-negative bacteria. In more than 100 countries it has therapeutic use. This study is aimed to determine Cytotoxic of Levofloxacin effects on rat testis tissue. Materials and Methods: For this experimental study, we used 50 male wistar rats which must be about 250±1 g. The control group received no treatment, the witness group fed normal saline and treatment groups fed with 250 ml, 500 ml and 750 ml of levofloxacin (n=10). This stage must last 60 days long. After the examination procedure, blood sampling of rats' hearts has been done and the serum samples sent to medical diagnostic for hormonal tests. Results: This study showed that levofloxacin in used doses has no effect in testosterone level but 500 and 750 ml doses of the drug increase LH level, and 250 and 500 ml doses of drug increase FSH level of serum. Conclusion: According to changes which made in this study, the levofloxacin antibiotic is one of the factors which causes disturbance in testis tissue and thereinafter hormonal disorder that should be noticed in prescription time.