P-67: The Comparison of the IVF Outcome betweenThree Methods of Induction Ovulationin PCOS Patients

Background: Polycystic ovarian syndrome (PCOS) is the most important cause of oligoovulation and anovulation in women of reproductive age and in infertile women . Several approaches have been proposed to induce ovulation in pcos pastients and gonadotropins are the classical and effective therapeutic options . This study was carried out with the Backgrounds of comparing of fertility rate with anly FSH , protocol , HMG protocol and combination of FSH and HMG for induction ovulation. Materials and Methods: 95 infertile women , by pcos diagnosis , in accordance with Rotterdam criteria who had been admitted to Montaserieh infertility center in mashhad , were selected 25 patients were induction ovulation by recombinant FSH ,35 patients by HMG , and 35 patients by a combination of FSH and HMG . Assessment was done in the ninth day of the menstrual cycle and the day of HCG injection by intravaginal sonography . The mean size and number of follicles in each ovary and the endometrial thickness was measured and recorded .After retruval of the ovucyts and incubating with sperms in lab was done the embryo transfer , two weeks after the fertilitzation the βHCG test was done and if the testwas positive , transvaginal ultrasound was done for FHR after 6 weeks. And if the result was positive fertility would be confirmed. After data collection and entry statistical analysis (t test , ANOVA and chi squre test ) on the basis of the hypothesis , with a significanc level of p=0.05 was performed using SPSS software. Results: Considering the response to treatment endometrial thickness , mean number and size of follicolles in the ninth day of menstrual cycle and day of HCG injection are the same. Only the mean numbers of follicles in the right ovary in the ninth day of menstrual cycle in three groups were significantly different (p=0.032) Other variables in three groups did not show a significant difference. Conclusion: In this study, the result of treatment of PCOS patients lug induction ovulation methods such as FSH, HMG, or combination of them, demonstrated no differents in fertility outcome. Although fertility rate of FSH group was more than of other groups, this might be attributed to the increased level of endogenic LH in PCOS patients.