P-5: Evaluation of The Effect of Sulpiride As An Atypical Antipsychotic Drug, on The Serum Levels of Prolactin, LH, FSH and Testosterone in Adult Male Mice

Background: Prescription of the atypical antipsychotic drugs like as Sulpiride for the treatment of schizophrenic patients was increased because of their less side effects. This study was aimed to evaluate the effect of sulpiride on hormonal milieu of adult male mice namely their serum level of prolactin and sexual hormones. Materials and Methods: 24 adult male mice were divided in three groups as test, control sham and control. The test mice were received 40 mg per kg sulpiride solution, daily for 45 days IP. Mice in the control sham were received the solvent only. Prolactin, LH, FSH and testosterone were measured in the serum samples of all mice and data was analyzed by statistical methods. Results: A significant increase in serum prolactin levels was found in the treated mice which were along with a significant decrease of LH, FSH and testosterone levels. No significant differences were found between control sham and control mice. Conclusion: These findings indicate that sulpiride is able to induce reproductive dysfunctions via reduction of sexual hormones levels and induction of prolactin secretion.