P-234: Altered Epigenetic Marks on Chromatin Condensing Genes of Sperm in TESE Negative Men Referred to Royan Institute
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P-194: SEPT12-G800A Polymorphism in Azoospermic Infertile Men Referred to Royan Institute
Background: SEPTINS belong to a family of polymerizing GTP-binding proteins that are required for many cellular functions, such as vesicular trafficking, mitosis, membrane compartmentalization and cytoskeletal remodeling. Among all SEPTIN genes, SEPT12 is dominantly expressed in testis tissue of adults, known as an essential annulus component of mature sperm. Therefore, it is hypothesized that ...
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Background During mammalian spermatogenesis unique and dynamic epigenetic events occur leading to chromatin condensation. Through these events, histone demethylases such as JMJD1A play important roles in compaction of sperm chromatin, due to regulation of histone methylation dynamics and alteration of chromatin structure. As �histone methylation� is one of the best-characterized modifications i...
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Background: About 15% of couples worldwide suffer from infertility problem that half of these cases are related to male infertility. Spermatogenesis is a cumulative process and thousands of genes are involved in it. Change in one of these genes or their products can cause male infertility. Tex11 is a germ cell specific gene that is located on the X chromosome (Xq13.1 region). This gene was iden...
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Background: Telomeres play a dramatic role in sperm pronuclei formation and subsequently successful fertilization. The H2B family, member W, testis specific (H2BFWT) gene encodes a testis specific histone that colocalized with telomeric sequences and interfere in the dynamic rearrangement of telomeres at late stages of spermatogenesis. H2BFWT is essential for transmission of the telomeric chrom...
متن کاملP-123: Genetic Variation of AKAP3 Gene in Infertile Men with Abnormal Spermogram Referred to Royan Institute
Background One kind of sperm abnormality that leads to men infertility is short flagella sperms. In this defect, fibrous sheath and axoneme are disorganized, the sperms tail is short, the numbers of sperms in the semen fluid reduce and the sperms are immotile. There are also other kinds of oligoasthenoteratozospermia (OAT) disorder that causes infertility in men. A kinas anchoring protein 3 (AK...
متن کاملP-202: Reduced Expression of JMJD1A Histone Demethylase Gene in Testis Tissues of Infertile Men Referred to Royan Institute
Background: Epigenetic modifications are involved in different cellular processes through regulating chromatin dynamics. histone methylation is an important modification that can be dynamically regulated by histone methyltransferase and histone demethylase enzymes. JMJD1A (also known as JHDM2A and KDM3A) is a histone demethylase specific for H3K9me2/me1. JMJD1A is a key epigenetic regulator tha...
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عنوان ژورنال
دوره 8 شماره 2.5
صفحات 244- 244
تاریخ انتشار 2014-07-01
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