P-159: Immunological Aspect of Ectopic Pregnancy Genes
نویسندگان
چکیده مقاله:
Background: Toll-like receptors (TLRs) play a crucial role in early host defense against invading pathogens. Recognition of some bacterial pathogen associated molecular patterns (PAMPs) is mediated by TLR2, 4 and 5 while TLR3 distinguishes double stranded RNA. Interactions between the immune system and female reproductive system have important consequences for fertility and reproductive health. Infection of the fallopian tube (FT) can result in adverse reproductive outcomes including ectopic oregnancy (EP). EP is an abnormal pregnancy that occurs outside the uterus, most often in the FT. Little has been done regarding TLRs expression in abnormal pregnancy. Therefore our objective was to clarify TLRs expression in FTs of women carrying EP. Materials and Methods: Our samples were divided into two groups: Case and control groups. Case group was women underwent salpingectomy for EP. Control group was women with healthy tube underwent hysterectomy. For control group, women were injected with human chorionic gonadotropin (hCG) in 14 days leading up to hysterectomy to produce state of pseudo-pregnancy. Then biopsies from Infundibulum, Ampulla and Isthmus of FT were obtained from both groups. In this investigation TLR2, 3, 4, 5 genes expression was survey with RT-PCR. Also Q-PCR was used to compare quantitative expression of TLR2, 3, 4, 5 genes between two groups. Results: TLR2, 3, 4, 5 genes expression have been demonstrated in all regions of the FTs in both groups. Lower expressions of TLR2, 3, 4, 5 genes were detected in all parts of FTs of case in compare to control groups. Conclusion: Reduction in TLR2, 3, 4, 5 genes expression in fallopian tube could result in increasing of infection which predispose to EP.
منابع مشابه
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متن کاملEctopic Pregnancy E.P.
حاملگی نابجا به مواردی اطلاق می شود که لانه گزینی بلاستوسیت در هر مکانی خارج از حفره رحمی صورت گیرد. مکان هایی که تاکنون در آنها چنین ضایعه ای پدید آمده عبارتند از : حاملگی لوله ای، حاملگی شکمی، حاملگی گردن رحم و مکان های دیگر. هر چند که در این میان بیش از ۹۵٪ حاملگی های نابجا در لوله رحمی اتفاق می افتد، ولی حاملگی نابجا مترادف حاملگی لوله ای نیست، لکن متداولترین نوع آن می باشد.
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عنوان ژورنال
دوره 6 شماره 2
صفحات -
تاریخ انتشار 2012-09-01
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