P-141: The Comparsion of Glucose-6-Phosphate Dehydrogenase Level between Preeclamptic Postpartum Mothers and The Healthy Post-Mothers in Alzahra Hospital in Rasht,2011- 2012

Background: Preeclampsia has high prevalence and important complication. The relationship between Glucose- 6-Phosphate Dehydrogenas (G6PD) and preeclampsia are expressed previously but their relationships are controversial yet. Some studies confirm this possibility and some others dismiss it. So we decided to examine the relationship between G6PD activity and preeclampsia although it is not denoted this test as clinically useful predictor for preeclampsia. Materials and Methods: In this case-control study, women with gestational age more than 20 weeks with or without preeclampsia admitted to Al-Zahra Hospital were included. Exclusion criteria were gestational diabetes mellitus, history of diabetes, chronic hypertension, use of any particular drug during pregnancy, thyroid disease, history of high fever in pregnancy, RH-negative blood group, more than 35 years, multiple pregnancies, body mass index more than 35, vasculopathy, antiphospholipid antibody syndrome and all factors affecting on G6PD enzyme levels. Demographic variables and levels of G6PD enzyme, hemoglobin, red blood cells and reticulocytes were assessed. Then statistical analysis was done with SPSS. Results: In this study, 115 women with a mean age of 28.4 ± 5.4 years were studied. They divided in two groups: 58 postpartum women with preeclampsia and 57postpartum women without preeclampsia. Two groups were matched in age, gestational age, gravidity, hemoglobin and red blood cell level. The G6PD enzyme levels (p=0.0001) and reticulocyte levels (p=0.005) were significantly lower in women with preeclampsia. Conclusion: This study showed that G6PD enzyme and reticulocythe levels were significantly lower in women with preeclampsia. The result of previous studies were inconsistent with others. Therefore, it is suggested to survey further studies with larger sample to find exact relationship between G6PD and preeclampsia.