P-14: Effect of Oxcarbazepine on Male ReproductivePhysiology

Background: Oxcarbazepine is a widely used novel antiepileptic drug . In vitro electrophysiology studies indicate that oxcarbazepine produced blocked of voltagesensitive sodium channels , resulting in stabilization of hyper exited neural membranes , inhibition of propagation of synaptic impulses . In this research the effect of oxcarbazepine has been studied on the amount LH , FSH , testosterone Hormones and male Reproductive physiology . Materials and Methods: In this research 40 adult male was stricken to epilepsy used accidentally between the conferrings to neurological clinics of shiraz in four groups which each of them was consist of 10 members, was as follow: Control group not received each material and experimental groups was received 150,300,600 mg/day amount of oxcarbazepine as oral ( tablet ) for 30 days and after the termination of this period for measuring the amount LH , FSH , testosterone Hornones of blood shooting from cephalic vessels of hand . And obtaining result was analyzed , by using ANOVA , Duncan and Tukey Test . Results: According to the obtained result , the in plasma concentration of LH presented a significant increased at p