Onm-8: Association between Reproductive and Medical and Human Papilloma Virus Infection in Iranian Women

Background: Human Papilloma viruses (HPV) is the most common sexually transmitted infection (STI) and the most important pathogenic factor for cervical intraepithelial lesions and carcinoma therefore a significant source of morbidity and mortality worldwide. This study was designed to investigate reproductive and medical factors associated with HPV infection in women referred to Colposcopy clinic of Gynecological hospital in Tehran, Iran in 2102. Materials and Methods: The case-control study including 201 women with abnormal pap smear referred to clinic of Colposcopy. Case group composed of 01 women with diagnosis of Condyloma Acuminata in biopsy specimen of cervix or positive HPV Typing test for types 6, 00, 06, 01, 10, 13, 31- 61 and control group composed of 140 women without diagnosis of Condyloma Acuminata in biopsy specimen of cervix or negative HPV Typing for types 6, 00, 06, 01, 10, 13, 31- 61. Two group were matched according to Iranian-descent, being of reproductive age (03-42 years) and had LSIL/HPV result on Pap Smear Test. Their demographic characteristics, reproductive and medical history were gathered by standard questionnaire then analyze data were done by SPSS version 21, t test, Chi- square test, fisher exact and Logistics Regression. Results: Our finding showed that demographic characteristics including reduction of age (p=0.000), increasing age at first marriage (p=0.000), Self-employed spouse (p=0.001), reproductive factors including reduce number of pregnancy (p=0.000), reduction of sexual intercourse number per week (p=0.006), no consumption of OCP (p=0.001), history of withdrawal contraception method (p=0.002), medical factors including no history of urinary tract infection (p=0.002) and non genital warts (p=0.001) were significant risk factors for HPV infection. Conclusion: Some reproductive and medical factors associated with increasing incidence of HPV infection. So knowledge about these factors helps us to identify women at risk and follow them consciously.