Onm-1: The Association of Apoprotien E Polymorphisms with Recurrent Miscarriage in Iranian Women

Background: Thrombophilia has been viewed as a multigenic disorder rather than a monogenetic clinical phenotype and Apo E has been shown to play an important role in lipid metabolism in pregnancy. As individuals carrying the E4 allele of the ApoE gene have the highest risk for thrombosis, we evaluated the frequency of the Apo E4 genotype among women suffering from recurrent pregnancy loss. Materials and Methods: 81 women with a history of two or more consecutive spontaneous abortions were examined for their APO-E genotypes based on restriction fragment length polymorphism analysis of PCRamplified fragments including amino acid positions 112 and 158. The observed genotypes were compared with negative controls. Results: Women experiencing recurrent pregnancy loss had a significantly higher prevalence of Apo E3/4, E4/4 genotypes (19.75%) compared with control women (2.46%) (p=0.00001). Conclusion: Apo E4 polymorphism may contribute to the thrombophilic risk factors contributing to recurrent pregnancy loss.