Neonatal thrombocytopenia in the NICU of our series: etiology, predisposing factors, management and short-term outcome
نویسندگان
چکیده مقاله:
Background: Thrombocytopenia (TTP) is one of the most common neonatal hematological disorders. The causes of neonatal TTP are very various, leading to large differences in the clinical profile of the affected neonates. Therefore, the aim of this study was to investigate the characteristics, clinical diagnoses and short-term outcomes of neonatal TTP in Bahrami Children's Hospital. Material and Methods: This descriptive retrospective cross-sectional study was conducted on all neonates admitted to the neonatal intensive care unit (NICU) of Bahrami Children's Hospital in 2017-2019. The infants diagnosed with neonatal TTP, defined as a platelet count of <150000 on at least 2 occasions, were retrospectively evaluated. Data on patients' TTP and short-term outcomes were reported. Incomplete medical records were excluded from the study. Results: Out of 2000 neonates, 210 patients were diagnosed with neonatal TTP with a prevalence of 10.5%. Totally, 60 and 71.4% of infants were premature and underweight, respectively. Moreover, 30 and 20.9% of infants had premature and severe TTP, respectively. The most common clinical diagnosis was sepsis (68.1%). The mean length of stay on NICU was 12.3±9.5 days. Furthermore, 9.5, 20.9 and 10.4% of infants had severe bleeding at least once, received platelet injections and expired during their stay on the NICU, respectively. Conclusion: The prevalence of neonatal TTP was 10.5%. Despite the relatively high prevalence of preterm birth, low-birth weight and sepsis, the majority of our neonates recovered. Prospective studies are recommended to investigate the role of each predisposing factor in the development and outcome of neonatal TTP.
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عنوان ژورنال
دوره 8 شماره 2
صفحات 721- 728
تاریخ انتشار 2022-09
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