Kisspeptin-13 ameliorates memory impairment induced by streptozotocin in male rats via cholinergic system

نویسندگان

  • Maryam Pourmir Department of Physiology, Faculty of Medicine, Guilan University of Medical Sciences, Rasht, Iran
  • Parvin Babaei Department of Physiology, Faculty of Medicine, Guilan University of Medical Sciences, Rasht, Iran
چکیده مقاله:

Introduction: Kisspeptin-13 (KP-13) is a novel endogenous factor, increases synaptic transmission and is involved in several behavioral functions such as anxiety, locomotion, epilepsy and avoidance learning. However, the role of this peptide on cognition has not been well clarified yet. Here we studied the effect of kisspeptin-13 pretreatment on spatial learning and also interaction with cholinergic and adrenergic systems. Methods: Eighty adult male Wistar rats were divided into 10 groups: saline + saline; saline + STZ; KP-13 + STZ; propranolol + STZ; prazosin + STZ; atropine + STZ; saline + KP-13 + STZ; propranolol + KP-13 + STZ; prazosin + KP-13 + STZ; atropine + KP-13+ STZ. Streptozotocin (STZ) (3mg/Kg) was administrated intracerebroventricularly (i.c.v), kisspeptin-13 was infused (1μg/2μl, i.c.v) 30 minutes before STZ and antagonists were infused (i.p) 30 minutes before kisspeptin-13. Memory performance was measured 14 days after STZ injection using Morris Water Maze (MWM) consisting of 4 blocks and one probe tests. Results: Pretreatment with kisspeptin-13 ameliorated acquisition (p = 0.001) and retrieval of memory impaired by STZ (P = 0.011). Moreover, we found that injection of atropine, but not propranolol or prazocin was able to reverse the memory enhancement caused by kisspeptin-13 (P = 0.037). Conclusion: Our findings indicate that facilitatory action of kisspeptin-13 on the spatial learning and memory in STZ-induced Alzheimer’s is mediated, at least in part, through cholinergic systems.

برای دانلود باید عضویت طلایی داشته باشید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

kisspeptin-13 ameliorates memory impairment induced by streptozotocin in male rats via cholinergic system

introduction: kisspeptin-13 (kp-13) is a novel endogenous factor, increases synaptic transmission and is involved in several behavioral functions such as anxiety, locomotion, epilepsy and avoidance learning. however, the role of this peptide on cognition has not been well clarified yet. here we studied the effect of kisspeptin-13 pretreatment on spatial learning and also interaction with cholin...

متن کامل

The effect of intracerebroventricular administration of insulin on memory impairment-induced by scopolamine in male rats

Introduction: Cholinergic neuronal deficiency is one of the main causes of Alzheimer's pathology, which leads to learning and memory impairment. Scopolamine is a muscarinic cholinergic antagonist commonly used to induce Alzheimer's disease (AD). Insulin also regulates learning and memory function. Thus, the aim of this study was to determine the effect of central administration of insulin on pa...

متن کامل

Metformin ameliorates learning and memory deficits in streptozotocin-induced diabetic rats

Background and Objective: Diabetes mellitus (DM) in long-term is associated with learning and memory decline. Metformin is an anti-diabetic drug with antioxidant and memory-improving effects. Thus, this research study was conducted to assess the effect of metformin on learning and memory in diabetic rats. Materials and Methods: In the present study, male Wistar rats (n=32) were randomly assign...

متن کامل

Role of the cholinergic muscarinic receptors of the CA1 area in the memory impairment induced by iron oxide nanoparticle in adult male rats

Objective(s): Nanoparticles of iron oxide (nFe2O3) are widely used in medicine and industry and could interfere with the brain processes associated with memory. The involvement of muscarinic cholinergic receptors in the process of memory formation has been confirmed. The present study aimed to investigate the possible interference of the cholinergic muscarinic receptors of the dorsal hippocampa...

متن کامل

Naringin ameliorates cognitive deficits in streptozotocin-induced diabetic rats

Objective(s):Previous research demonstrated that diabetes is one of the leading causes of learning and memory deficits. Naringin, a bioflavonoid isolated from grapefruits and oranges, has potent protective effects on streptozotocin (STZ)-induced diabetic rats. Recently, the effects of naringin on learning and memory performances were monitored in many animal models of cognitive impairment. Howev...

متن کامل

Could Melissa Officinalis Extract Restore Streptozotocin-Induced Spatial Memory Impairment in Rats?

Introduction: Alzheimer disease is a progressive and irreversible neuropsychiatric disorder. Melissa Officinalis improves anxiety and clinical dementia symptoms caused by AD therefore, the purpose of the present study was to evaluate the effect of Mellisa extract on spatial memory deficit induced by STZ in MWM examination of male wistar rats. Methods: In the present study, 112 male wista...

متن کامل

منابع من

با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

ذخیره در منابع من قبلا به منابع من ذحیره شده

{@ msg_add @}


عنوان ژورنال

دوره 20  شماره None

صفحات  38- 47

تاریخ انتشار 2016-02

با دنبال کردن یک ژورنال هنگامی که شماره جدید این ژورنال منتشر می شود به شما از طریق ایمیل اطلاع داده می شود.

کلمات کلیدی

میزبانی شده توسط پلتفرم ابری doprax.com

copyright © 2015-2023