Interactive effect of exercise and Anvillea garcinii extract on cholesterol and thyroid hormones in hypercholesterolemia rats

Introduction: Thyroid hormones are one of the most important hormones affecting the bodychr('39')s metabolic function, so the treatment of hormonal disorders of this gland using low-risk drugs and methods such as exercise and herbal remedies is effective. Hence, the purpose of this study was to evaluate the effect. Interactive exercise and aniseed extract of Anvillea garcinii extract on Cholesterol and thyroid hormones in hypercholesterolemia rats. Materials and Methods: This study is of experimental type and 40 male Wistar rats randomly were divided into five groups of eight, including healthy control group (Con), control hypercholesterolemia (Hc), anvil extract at a dose of 100 mg/kg, (Ext), training group (E ), Extract-exercise (E-Ext). Endurance exercise was performed for 8 weeks, 30 minutes and three sessions per week at a speed equivalent to 14-17 m/min. Then, the amount of biochemical factors including cholesterol, TSH, T3 and T4 was sampled and measured by the kit in order to determine the differences between groups ANOVA test used. Results: The results showed that the difference between the mean levels of cholesterol (p<0.0001), T4, T3 and TSH (p<0.0001) between the groups was significant. The results of Tukey post hoc test showed, the difference between cholesterol level in the extract-exercise group compared to the control of hypercholesterolemia (p<0.001) and extract (p<0.05) was also significant compared to the control group of hypercholesterolemia (p<0.008). Difference between T4 level in the extract group-exercise compared to hypercholesterolemia control, extract and exercise (p<0.001) and T3 level in the extract group exercise compared to hypercholesterolemia control (p<0.05), extract (p<0.0001) and exercise (p<0.05) were significant. The amount of TSH in the extract group of exercise compared to the control of hypercholesterolemia (p<0.001), extract (p<0.001) and exercise (p<0.05) and also the exercise group in relation to the extract (p<0.05) a significant increase was observed. Conclusion: Consumption of plant extracts along with exercise have the best effect on cholesterol and thyroid hormones levels.