INFLUENCE OF CCK RECEPTOR AGONIST AND ANTAGONISTS ON TOLERANCE INDUCED TO ANTIPENTYLENETETRAZOL ACTIVITY OF DIAZEPAM
نویسندگان
چکیده مقاله:
In the present study, the effects of caerulein and CCK receptor antagonist< on tolerance to the anti-pentylenetetrazol activity of diazepam has been studied. Different doses of diazepam (20, 30, 35, 40 and 50 mg/kg) were administered intraperitoneally for a period of 6 days in order to induce tolerance to diazepam. 48 h after the last dose of diazepam, a test dose of diazepam was tested for antipentylenetetrazol activity. When animals were treated with caerulein or the CCK receptor antagonists MK -329 and L-365,260, only L-365,260 reversed the tolerance to diazepam. It may be concluded that CCK-B receptor mechanisms may interact with tolerance induced by diazepam.
منابع مشابه
influence of cck receptor agonist and antagonists on tolerance induced to antipentylenetetrazol activity of diazepam
in the present study, the effects of caerulein and cck receptor antagonist< on tolerance to the anti-pentylenetetrazol activity of diazepam has been studied. different doses of diazepam (20, 30, 35, 40 and 50 mg/kg) were administered intraperitoneally for a period of 6 days in order to induce tolerance to diazepam. 48 h after the last dose of diazepam, a test dose of diazepam was tested for ant...
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عنوان ژورنال
دوره 12 شماره 4
صفحات 365- 369
تاریخ انتشار 1999-02
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