Impact of liver function on serum level of prostate specific antigen (PSA) in cirrhotic patients, before and after receiving liver transplant.
نویسندگان
چکیده مقاله:
Introduction: Prostate cancer is the most prevalent malignancies among males. Prostate specific antigen (PSA) is used for screening of this malignancy. Serum levels of PSA is influenced by liver function. This study evaluate variations of serum levels of PSA amongst cirrhotic patients, before and after receiving liver transplantation. Material and methods: all cirrhotic males older than 45 y/o in the waiting list of liver transplant, enrolled in the study. After receiving a medical history and checking a total PSA (tPSA), patients who has abnormality excluded from the study. So, 60 patients who underwent liver transplantation surgery, with a normal 3month follow up liver function tests (LFT) included. Thereafter a tPSA level was checked again. Ultimately 30 patients perform a tPSA after a successful liver transplant. Results: in these 30 patient series, the mean age was 57, and average tPSA before liver transplant was 0.4ng/dl (range: 0.7-1.6), and after transplant was 1.6 (range: 0.2-7.3). Wilcoxon test revealed significant differences between pre and post-transplant PSA levels (P˂0.001, Z= -4.68). Conclusion: serum levels of PSA, rises after a successful liver transplant. In cirrhotic patients, PSA levels may not be authentic. In this study, PSA levels rose by 1.2ng/dl post-transplant. This study revealed that tPSA may nether reliable nor sensitive enough as a routine screening test for cirrhotic patients; and seems to determine lower levels for this mean.
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عنوان ژورنال
دوره 3 شماره 1
صفحات 0- 0
تاریخ انتشار 2019-03
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