Evaluation of the Correlation between CD44, Tumor Prognosis and the 5-Year Survival Rate in Patients with Oral Tongue SCC

نویسندگان

  • Ebrahim Karimi Otorhinolaryngology Research Center, Tehran University of Medical Siences, Tehran, Iran.
  • Farzad Yazdani Department of Pathology, Amir Alam Hospital, Tehran University of Medical Siences, Tehran, Iran
  • Mohammad Reza Firouzifar Department of Otorhinolaryngology, Amir Alam Hospital, Tehran University of Medical Siences, Tehran, Iran.
  • Nasrin Yazdani Otorhinolaryngology Research Center, Tehran University of Medical Siences, Tehran, Iran.
  • Reza Kaboodkhani Department of Otorhinolaryngology and Head and Neck Surgery, Shiraz University of Medical Sciences, Shiraz, Iran.
چکیده مقاله:

Introduction: 90% of the tumors in the head and neck are squamous-cell carcinomas (HNSCC), which have overall 5- year survival rate between 50% -60%. CD44 has been shown to be associated with the prognosis.  Materials and Methods: Biopsy specimens of 51 patients with oral tongue SCC were evaluated by Immunohistochemistry (IHC) for the CD44 antibody.  Results: There was no significant correlation between CD44 and survival (P=0.77), age (P=0.4), CD44 and lymph node metastasis (P=0.87), sex (P=0.947), smoking (P=0.287) and tumor size (P=0.813). However, there was significant correlation between smoking and survival.   Conclusion: There are widespread discrepancies among the findings in the literature regarding the prognosis of CD44 expression in OCSCC. Our study shows that the expression of CD44 is not a marker of aggressive behavior in oral tongue SCC. Consequently, CD44 cannot be considered as handy tool to establish the tumor behavior, prognosis and 5- year survival rate of these tumors. 

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منابع مشابه

evaluation of the correlation between cd44, tumor prognosis and the 5-year survival rate in patients with oral tongue scc

introduction: 90% of the tumors in the head and neck are squamous-cell carcinomas (hnscc), which have overall 5- year survival rate between 50% -60%. cd44 has been shown to be associated with the prognosis.  materials and methods: biopsy specimens of 51 patients with oral tongue scc were evaluated by immunohistochemistry (ihc) for the cd44 antibody.  results: there was no significant correlatio...

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عنوان ژورنال

دوره 28  شماره 6

صفحات  407- 411

تاریخ انتشار 2016-11-01

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