Clinical evaluation of 25% metronidazol gel application in surgical treatment of advanced chronic periodontitis

Clinical evaluation of 25% metronidazol gel application in surgical treatment of advanced chronic periodontitis Dr. A. Kamali* - Dr. A. Ansari** - Dr. F. Azabdaftaran**** - Assistant Professor of Periodontics Dept. - Faculty of Dentistry – Kerman University of Medical Sciences. **- Assistant Professor of Pharmacology Faculty - Kerman University of Medical Sciences. ***- Medical practitioner Background and Aim: Different drugs are used in the treatment of periodontal diseases be-cause of their different bacterial sources. This aim of this study was to evaluate clinically the application of metronidazol gel 25% in surgical treatment of advanced chronic periodontitis.Materials and Methods: In this randomized double blind clinical trial 33 patients, age ranging from 37 to 42 years, with advanced chronic periodontitis were selected. They were not affected with any systemic disease. Following phase I of treatment, patients with symmetric pockets of 7–8 mm depth were selected and modified widman flap was elevated for them. In the experi-mental group, the gel was applied before suturing. Patients were dismissed without any antibi-otic prescription. Sutures were removed after one week and pocket depths were recorded 6 – 7 months later. Results: The mean pocket depth reductions were 5.03 mm and 5.21 mm in control and ex-perimental groups, respectively. Intergroups analytical test (Paired t – test) showed significant different between pocket depths of two groups (P<0.02). Conclusion: Considering the slight differences in pocket depth reductions between two groups, more research is recommended for the application of this gel in the treatment of chronic periodontitis, however its non-surgical and local application for the treatment of re-fractory periodontitis can be thoroughly beneficial. Key words: 25% Metronidazole gel – Flap – Chronic periodontitis – Pocket depth