Assessment of Maternal Vitamin D and CRP Plasma Levels Correlation to Preeclampsia and Its Severity: Case Control Study

Introduction:Preeclampsia is a serious, inflammatory-mediated hypertensive disorder of pregnancy affecting approximately 8% of all pregnancies. Based on recent studies, women with vitamin D deficiency may have an increased risk of developing preeclampsia. The aim of the study was to evaluate the vitamin D and CRP levels and explore the role and correlation between each other and also occurrence of preeclampsia. Material and methods:55 preeclamptic women and 55 healthy pregnant women were selected from Kamali hospital in karaj, Iran. 6 ml of venous blood sample was collected from each pregnant woman and the serum 25-OH-D and CRP levels were measured by ELISA which reported in ng/mL and mg/dL, respectively. Data were analyzed by independent t-test, Mann-Whitney U test, Chi square and logistic regression. Results:Preeclamptic women (n=55) were noted to have decreased total 25-OH-D and elevated CRP levels relative to healthy control women (n=55; P<0.001). This difference in vitamin D deficiency remained significant after adjustment for maternal age and BMI [odds ratio (OR) = 12.54, confidence interval (CI) = 1.03–154.95, P=0.047]. Conclusion: These results showed that vitamin D deficiency and abnormal inflammatory status have a statistically significant relationship with preeclampsia and support the hypothesis that vitamin D deficiency may be a risk factor for preeclampsia in the context of an inflammatory condition.