گزارش 4 مورد بوتولیسم غذائی در یک خانواده

Botulism is caused  by a neurotoxin produced from the anaerobic,    Spore-forming bacterium clostridium botulinum. Botulism have four     clinical  forms:1)Food –borne botulism   2)Wound botulism    3)Infant botulism    4)undetermined botulism, that the  most common is food-borne  botulism.     Botulism in humans is usually caused by toxin types A, B, and E, that  is a rare    but serious disease. Botulism is characterized by symmetric , descending ,    flaccid paralysis of motor and autonomic nerves. Petosis , blurred vision ,    diplopia,dysphagia  and  dysarthria  are  common initial  complaints. The     diagnosis of food-borne botulism is based on clinical findings with the     detection of toxin in patient,s stool, serum or detection of clostridium      botulinum   bacteria in  the  stool .           In this  study  four  patients   with  food-borne botulism  are  discussed.    The most common presentations of  patients  were  weakness in  exterimities,    petosis, blurred vision, diplopia, and dysphagia. The patients  had  no  fever     and  no sensory dysfunction. In three stool specimens of  patients   reported     positive  for  toxin  of  botulinum.           All of the patients  treated  with  trivalent  equine  antitoxin(ABE). The    patients improved completely after 1.5 months  of  discharge. Conclusion:    In any  acute  symmetric, descending , flaccid  paralysis patient , we should    think about botulism.