میزان بروز آمنوره ناشی از شیمی درمانی ادجوانت در زنان غیریائسه مبتلا به سرطان پستان

Background and purpose: Although adjunct chemotherapy may increase life in non-menopausal breast cancer patients، however، it may cause short-term complications such as nausea، vomiting، alopecia، as well as long-term complications in ovarian failure and premature menopausal. The objective of this study was to investigate chemotherapy-induced secondary amenorrhea in non-menopausal women with breast cancer. Materials and methods: A descriptive design (case series) was preformed on fifty breast cancer patients، non-menopausal (normal mense) and chemotherapy in Ramsar Emam Sajad Hospital Oncology unit from 2007 to 2008. Sampling was consecutive. Data gathering method was questionnaire & blood sampling (FSH & Progesterone) for prior and 12 months after the end of chemotherapy. Data was analyzed by paired-t، independent-t and one-way ANOVA tests. Results: Results showed that 62% of patients were amenorrhea 12 months after the end of chemotherapy. Results showed that there was no meaningful relationship between age، hormone therapy، disease stage، node-positive and ER & PR status to amenorrhea however، there was a meaningful relationship between duration of treatment، type and dose of chemotherapy to amenorrhea. Conclusion: In pre-menopausal patients with breast cancer، receiving cytotoxic chemotherapy against tumor cells، amenorrhea may occur do to ovarian failure.